| Active Ingredient | TIANEPTINE |
| Therapeutic Class | ANTIDEPRESSANTS MISCELLANEOUS |
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| Active Ingredient | CLOZAPINE |
| Therapeutic Class | ATYPICAL ANTIPSYCHOTICS |
| Indications |
Schizophreniain patients unresponsive to, or intolerant of, conventional antipsychotic drugs. |
| Caution | Anorexia; constipation; hypersalivation; malaise; speech disorders; urinary incontinence. |
| Dose Range | Adult:12.5 mg once or twice on the first day followed by 25 mg once or twice on the second day. Daily dosage may be increased gradually in step s of 25 to 50 mg. Maximum 900 mg per day . Adult 60 years and over: dose increments should be restricted to 2 |
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| Active Ingredient | OLANZAPINE |
| Therapeutic Class | ATYPICAL ANTIPSYCHOTICS |
| Indications | Schizophrenia, moderate to severe mania associated with bipolar disorder. |
| Caution | Arthralgia, hypercholesterolaemia, hypertrigly ceridaemia, increased appetite, malaise, oedema. |
| Dose Range | Adult: 5-20 mg daily . |
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| Active Ingredient | QUETIAPINE |
| Therapeutic Class | ATYPICAL ANTIPSYCHOTICS |
| Indications | Treatment of schizophrenia, bipolar disorder. |
| Caution | Rate of dose titration may need to be slower and the daily dose lower in elderly patients. Asthenia; dysarthria; dyspnoea; elevated plasma-ca concentrations; elevated plasma-trigly ceride concentrati More ... |
| Dose Range | Adult: Schizophrenia: 25 mg twice daily for day 1, then 50 mg twice daily for day 2, then 100 mg twice daily for day 3, then 150 mg twice daily for day 4, then, adjusted according to response, usual dose 300–450 mg daily in 2 divided doses. Maximum 750 mg |
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| Active Ingredient | QUETIAPINE XR |
| Therapeutic Class | ATYPICAL ANTIPSYCHOTICS |
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| Active Ingredient | RISPERIDONE |
| Therapeutic Class | ATYPICAL ANTIPSYCHOTICS |
| Indications | Manic bipolar I disorder, Schizophrenia. |
| Caution |
Increase body temperature, cerebrovascular accident in the elderly , drug-induced tardive dystonia, excessive thirst, hypergly cemia,hypothermia, seizure, syncope, tardive dyskinesia, transient isch More ... |
| Dose Range |
Manic bipolar I disorder: Monotherapy with lithium or valproate; intially, 2-3mg orally once a day with dosage adjustments of 1mg/day increments. Schizophrenia: Initially 1mg twice daily , with 1mg twice daily increments on the second and third day |
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| Active Ingredient | ZIPRASIDONE |
| Therapeutic Class | ATYPICAL ANTIPSYCHOTICS |
| Indications | Schizophrenia, acute manic or mixed episodes associated with bipolar disorder. |
| Caution |
Orthostatic hypotension at the start of therapy. Somnolence, urticaria, gastrointestinal disturbances, dizziness, flu-like symptoms, headache, agitation, confusion, dyspnoea. |
| Dose Range |
Adult: Schizophrenia: 20-80mg twice a day with food. Bipolar Disorder: 40-80mg twice a day |
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| Active Ingredient | HALOPERIDOL |
| Therapeutic Class | BUTYROPHENES |
| Indications | Symptomatic treatment of psychotic disorders. |
| Caution | Extrapy ramidal side effects common but little drowsiness. May develop hypotension and cholinergic effects. Not approved in children less than 3yrs of age. C.f. prescribing in liver and renal disea More ... |
| Dose Range |
Adult: 0.5-5mg 2-3 times daily to a maximum of 30mg daily in divided doses. i.m: initially 2-10mg then every 4-8 hours according to response to total max. of 18mg daily. Pediatric 3-12 yrs: (15- 40kg) Initial dose: 0.25mg-0.5mg/day in 2-3 divided doses i |
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| Active Ingredient | CHLORDIAZEPOXIDE |
| Therapeutic Class | PHENOTHIAZINES |
| Indications |
For short term relief of anxiety and tension in neuroses. Adjunct in acute alcohol withdrawal. Also see Major Tranquliser on p.265. |
| Caution | Dizziness, drowsiness, ataxia and slurred speech. Short term usage recommended because they are habit forming. Not recommended in children. C.f. prescribing in liver and renal disease p. 12; 25. |
| Dose Range | Anxiety: 10mg 3 times daily increased if necessary to 60-100mg daily in divided doses. Alcohol withdrawal Syndrome: 25-100 mg repeated as needed after 2 to 4 hours, up to a maximum of 300 mg daily . Elderly: half adult dose. |
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| Active Ingredient | CHLORPROMAZINE |
| Therapeutic Class | PHENOTHIAZINES |
| Indications | To control psychotic excitement. |
| Caution | Drowsiness, precipitating confusional psychoses and postural hypotension with injections, nasal congestion and dry mouth. C.f. prescribing in liver and renal disease p. 12; 26. |
| Dose Range |
Oral: 75-300mg daily in divided doses. (But up to 1g may be given in p sy choses). Inj: 25-50mg p er every 6-8 hours. |
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| Active Ingredient | FLUPHENAZINE |
| Therapeutic Class | PHENOTHIAZINES |
| Indications |
Schizophrenia and other psychoses. Depot injections for ambulant psychotics. |
| Caution | Parkinsonian extrapy ramidal effects, drowsiness, hypotension. |
| Dose Range | Adult: Tab: 2-10mg daily in divided doses. Inj: 12.5-100mg monthly. |
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| Active Ingredient | PERPHENAZINE |
| Therapeutic Class | PHENOTHIAZINES |
| Indications | Useful in paranoid states. [Schizop hrenia] |
| Caution | Less drowsiness and hypotension. Less blood dycrasias of jaundice. See chlorp romazine. C.f. prescribing in liver and renal disease p.16; 34. Not recommended in children under 14yrs. |
| Dose Range |
Adult: 12-24mg daily in divided doses. Elderly: Use quarter-half of adult dose. |
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| Active Ingredient | PROCHLORPERAZINE |
| Therapeutic Class | PHENOTHIAZINES |
| Indications | Minimum use in psychiatry . Antiemetic. |
| Caution | c.f. prescribing in liver and renal disease p.17;35. See chlorpromazine. |
| Dose Range |
Psychiatry: 25-100mg daily in divided doses. Anti-emetic: 5-10mg 2-3 times daily . |
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| Active Ingredient | THIORIDAZINE |
| Therapeutic Class | PHENOTHIAZINES |
| Indications | When heavy sedation is not required. For restless, confused geriatric patients at night. Schizophrenia and other psychoses |
| Caution | Causes less extrapy ramidal problems. Possibility of retinal pigmentation after prolonged usage and at doses over the maximum. More likely to induce hypotension. Contraindicated in cardiac disease. C More ... |
| Dose Range | Adult: 150-300mg in 3 divided doses to a maximum of 800mg/day . Elderly: 30-100mg daily . Pediatric: 0.5mg/kg/day in divided doses to a maximum of 3mg/kg/day . |
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| Active Ingredient | TRIFLUOPERAZINE |
| Therapeutic Class | PHENOTHIAZINES |
| Indications | Paranoid and withdrawn states. |
| Caution | Extrapy ramidal symptoms, ocular pigmentation. C.f. prescribing in liver and renal disease p. 18; 38. Safety and efficacy have not been established in children under 6yrs of age. |
| Dose Range |
Adult: 2- 5 mg twice daily, gradually increased to a usual range of 15-20 mg daily; in severe or resistant psychoses daily doses of 40 mg or more have been given. Pediatric under 12 yrs: Up to 5mg once daily . |
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| Active Ingredient | FLUPENTHIXOL |
| Therapeutic Class | THIOXANTHENES |
| Indications |
Maintenance in schizophrenia and other psychoses. Depot injection for ambulant psychotics. |
| Caution | Extrapy ramidal symptoms. Tardive dyskinesia; pregnancy . Pain may occur at injection site. C.f. Prescribing in liver and renal disease p. 13; 29. |
| Dose Range | 20-40mg rep eated at 2-4 week intervals. |
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| Active Ingredient | ZUCLOPENTHIXOL |
| Therapeutic Class | THIOXANTHENES |
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| Active Ingredient | ANTIDEPRESSANTS |
| Therapeutic Class | ANTIDEPRESSANTS |
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| Active Ingredient | TRANQUILLIZERS |
| Therapeutic Class | TRANQUILIZERS |
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| Active Ingredient | DOXAPRAM |
| Therapeutic Class | RESPIRATORY-CEREBRAL STIMULANTS |
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