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Drugs to be avoided or used with caution in liver disease
Active Ingredient Comments
Nitrazepam see Anxiolytics and hypnotics
Nitrofurantoin Cholestatic jaundice and chronic active hepatitis reported
Nitroprusside Avoid in severe liver disease
Norethisterone see Progestogens
Norfloxacin see 4-Quinolones
Nortriptyline see Antidepressants, Tricylic
NSAIDs Increased risk of gastro-intestinal bleeding and can cause fluid retention; avoid in severe liver disease
Oestradiol see Oestrogens
Oestriol see Oestrogens
Oestrogens Avoid; see also contraceptives, Oral
Ofloxacin see 4-Quinolones
Omeprazole
Opioid Analgesics Avoid or reduce dose - may precipitate coma
Oral Contraceptives see Contraceptives, Oral
Oxazepam see Anxiolytics and Hypnotics
Oxytetracycline see Tetracyclines
Papaveretum see Opioid Analgesics
Paracetamol Dose-related toxicity - avoid large doses
Paroxetine see Antidepressants,SSRI
Pentazocine see Opioid Analgesics