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Drugs to be avoided or used with caution in liver disease
Active Ingredient Comments
Clofibrate Avoid in severe liver disease
Clomiphene Avoid in severe liver disease
Clomipramine see Antidepressants, Tricylics
Codeine see Opioid Analgesics
Contraceptives, Oral Avoid in active liver disease and in patients with a history of pruritus or cholestatis during pregnancy
Dantrolene Avoid - may cause severe liver damage
Demeclocycline see Tetracyclines
Desflurane Reduce dose
Desipramine see Antidepressants, Tricylic
Diazepam see Anxiolytics and Hypnotics
Diclofenac see NSAIDs
Dihydrocodeine see Opioid Analgesics
Diltiazem Reduce dose
Dimenhydrinate see Antihistamines
Diphenoxylate see Opioid Analgesics
Doxorubicin Reduce dose according to bilirubin concentration
Doxycycline see Tetracyclines
Epirubicin Reduce dose according to bilirubin concentration
Ergometrine Avoid in severe liver disease
Ergotamine Avoid in severe liver disease -risk of toxicity increased