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Drugs to be avoided or used with caution in liver disease
Active Ingredient Comments
Ceftriaxone Reduce dose and monitor plasma concen-tration if there is both hepatic and severe renal im-pairment
Chloral Hydrate see Anxiolytics and hypnotics
Chloramphenicol Avoid - increased risk of bone-marrow depression
Chlordiazepoxide see Anxiolytics and Hypnotics
Chlorothiazide see Thiazides
Chlorpheniramine see Antihistamines
Chlorpromazines see Antipsychotics
Chlorpropamide see Sulphonylureas
Chlortetracycline see Tetracyclines
Cholestyramine Interferes with absorption of fat-soluble vitamins and may aggravate absorption in primary biliary cirrhosis; likely to be ineffective in complete biliary obstruction
Choline Theophyllinate see Theophylline
Cimetidine Increase risk of confusion; reduce dose
Cinnarizine see Antihistamines
Ciprofloxacin see 4-Quinolones
Cisapride Half dose initially
Citalopram Use doses at lower end of range
Clarithromycin Hepatic dysfunction including jaundice reported
Clemastine see Antihistamines
Clindamycin Reduce dose
Clobazam see Anxiolytics and Hypnotics