| Active Ingredient | CLOZAPINE |
| Therapeutic Class | ATYPICAL ANTIPSYCHOTICS |
| Indications |
Schizophreniain patients unresponsive to, or intolerant of, conventional antipsychotic drugs. |
| Caution | Anorexia; constipation; hypersalivation; malaise; speech disorders; urinary incontinence. |
| Dose Range | Adult:12.5 mg once or twice on the first day followed by 25 mg once or twice on the second day. Daily dosage may be increased gradually in step s of 25 to 50 mg. Maximum 900 mg per day . Adult 60 years and over: dose increments should be restricted to 2 |
| Drug Interactions | |
| Pregnancy | |
| Breast Feeding |
| Active Ingredient | OLANZAPINE |
| Therapeutic Class | ATYPICAL ANTIPSYCHOTICS |
| Indications | Schizophrenia, moderate to severe mania associated with bipolar disorder. |
| Caution | Arthralgia, hypercholesterolaemia, hypertrigly ceridaemia, increased appetite, malaise, oedema. |
| Dose Range | Adult: 5-20 mg daily . |
| Drug Interactions | |
| Pregnancy | |
| Breast Feeding |
| Active Ingredient | QUETIAPINE |
| Therapeutic Class | ATYPICAL ANTIPSYCHOTICS |
| Indications | Treatment of schizophrenia, bipolar disorder. |
| Caution | Rate of dose titration may need to be slower and the daily dose lower in elderly patients. Asthenia; dysarthria; dyspnoea; elevated plasma-ca concentrations; elevated plasma-trigly ceride concentrati More ... |
| Dose Range | Adult: Schizophrenia: 25 mg twice daily for day 1, then 50 mg twice daily for day 2, then 100 mg twice daily for day 3, then 150 mg twice daily for day 4, then, adjusted according to response, usual dose 300–450 mg daily in 2 divided doses. Maximum 750 mg |
| Drug Interactions | |
| Pregnancy | |
| Breast Feeding |
| Active Ingredient | QUETIAPINE XR |
| Therapeutic Class | ATYPICAL ANTIPSYCHOTICS |
| Indications | |
| Caution | |
| Dose Range | |
| Drug Interactions | |
| Pregnancy | |
| Breast Feeding |
| Active Ingredient | RISPERIDONE |
| Therapeutic Class | ATYPICAL ANTIPSYCHOTICS |
| Indications | Manic bipolar I disorder, Schizophrenia. |
| Caution |
Increase body temperature, cerebrovascular accident in the elderly , drug-induced tardive dystonia, excessive thirst, hypergly cemia,hypothermia, seizure, syncope, tardive dyskinesia, transient isch More ... |
| Dose Range |
Manic bipolar I disorder: Monotherapy with lithium or valproate; intially, 2-3mg orally once a day with dosage adjustments of 1mg/day increments. Schizophrenia: Initially 1mg twice daily , with 1mg twice daily increments on the second and third day |
| Drug Interactions | |
| Pregnancy | |
| Breast Feeding |
| Active Ingredient | ZIPRASIDONE |
| Therapeutic Class | ATYPICAL ANTIPSYCHOTICS |
| Indications | Schizophrenia, acute manic or mixed episodes associated with bipolar disorder. |
| Caution |
Orthostatic hypotension at the start of therapy. Somnolence, urticaria, gastrointestinal disturbances, dizziness, flu-like symptoms, headache, agitation, confusion, dyspnoea. |
| Dose Range |
Adult: Schizophrenia: 20-80mg twice a day with food. Bipolar Disorder: 40-80mg twice a day |
| Drug Interactions | |
| Pregnancy | |
| Breast Feeding |