| Active Ingredient | SUCRALFATE |
| Therapeutic Class | GI PROTECTANTS |
| Indications | Gastric and duodenal ulcers, chronic gastritis. |
| Caution | Constipation, gastric discomfort, diarrhoea. c.f. prescribing in renal disease p. 37. |
| Dose Range | Adult and children 15 years and over: 1g every 6 hours (1 hour before meals and at bedtime) or 2g every 12 hours (on rising and at bedtime). Pediatric 1 month-2 yrs: 0.25g 4-6 times daily ; 2-12 yrs: 0.5g 4-6 times daily ; 12-15 yrs: 1g 4-6 times dai |
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| Breast Feeding |
| Active Ingredient | ESOMEPRAZOLE |
| Therapeutic Class | PROTON PUMP INHIBITORS |
| Indications | |
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| Breast Feeding |
| Active Ingredient | LANSOPRAZOLE |
| Therapeutic Class | PROTON PUMP INHIBITORS |
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| Breast Feeding |
| Active Ingredient | OMEPRAZOLE |
| Therapeutic Class | PROTON PUMP INHIBITORS |
| Indications | Duodenal and gastric ulcers. Gastroesophageal reflux disease. |
| Caution |
Constipation, diarrhea, headache, nausea, rash. Capsule is to be swallowed whole. c.f. prescribing in liver disease p. 16. |
| Dose Range | Peptic ulcer: 20 - 40 mg daily depending on severity ; 4 weeks for duodenal ulcer and 8 weeks for gastric ulcer; maintenance: 20 mg once daily .GERD: 20mg once daily for 4 weeks, followed by a further 4 - 8 weeks if not fully healed. Take before break |
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| Breast Feeding |
| Active Ingredient | PANTOPRAZOLE |
| Therapeutic Class | PROTON PUMP INHIBITORS |
| Indications | Short term treatment of GERD (7-10 day s). |
| Caution | Diarrhea, nausea, headache. Safety and efficacy not established in children. |
| Dose Range | i.v: 40mg once daily for 7-10 day . See protocol pg. xiii section 7 and 8. |
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| Breast Feeding |
| Active Ingredient | RABEPRAZOLE |
| Therapeutic Class | PROTON PUMP INHIBITORS |
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| Active Ingredient | MESALAZINE |
| Therapeutic Class | GI PROKINETIC AGENTS |
| Indications | Treatment of acute attacks of mild to moderate ulcerative colitis; maintenance of remission of ulcerative colitis. |
| Caution | Headache and gastrointestinal disturbances. |
| Dose Range | g PO four times daily for 8 weeks |
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| Breast Feeding |
| Active Ingredient | METOCLOPRAMIDE |
| Therapeutic Class | GI PROKINETIC AGENTS |
| Indications |
Facilitation of small bowel intubation in X -ray procedures. Esophageal reflux. Vomiting associated with cytotoxic agents. |
| Caution | Restlessness, drowsiness, dizziness, fatigue, insomnia, headache. Exercise caution in activities requiring mental alertness. c.f. prescribing in renal disease p. 32. Avoid use with alcohol More ... |
| Dose Range | Adult: Tabs:5-10mg 3 times daily . Pediatric: Oral 0.3-0.75mg/kg p er day in 3-4 divided doses. Intravenous: 2.5-10mg as a single dose (0.1mg/kg as a single dose in children under 6 y ears). |
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| Breast Feeding |
| Active Ingredient | MISOPROSTOL |
| Therapeutic Class | GI PROKINETIC AGENTS |
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| Breast Feeding |
| Active Ingredient | MISCELLANEOUS GI DRUGS |
| Therapeutic Class | MISCELLANEOUS GI DRUGS |
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| Active Ingredient | DEFERASIROX |
| Therapeutic Class | HEAVY METAL ANTAGONISTS |
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| Breast Feeding |
| Active Ingredient | DESFERRIOXAMINE MESYLATE |
| Therapeutic Class | HEAVY METAL ANTAGONISTS |
| Indications | Iron-The heavy metal antagonists have the property of forming complexes with heavy metals and preventing or reversing the binding of metallic cations to body ligands |
| Caution | Initially up to 15 mg/kg/hour, max. 80 mg/kg in 24 hours, dose to be reduced after 4–6 hours, in severe cases, higher doses may be given.Arthralgia; bone disorder; fever; growth retardation; headache; More ... |
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| Breast Feeding |
| Active Ingredient | DIMERCAPROL |
| Therapeutic Class | HEAVY METAL ANTAGONISTS |
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| Active Ingredient | PENICILLAMINE |
| Therapeutic Class | HEAVY METAL ANTAGONISTS |
| Indications | Acute copper (or lead) poisoning, Wilson's disease. Third line drug for rheumatoid arthritis (to reduce cystine levels). |
| Caution |
Epigastric pain, nausea, rash c.f. prescribing in renal disease p. 34 |
| Dose Range | Adult: 1-2g daily in divided doses (In R. A: 125mg-250mg with doses increases over a 3-4 mth period to a maximum of 1.5g). Pediatric: 2.5-10mg/kg twice daily . |
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| Breast Feeding |
| Active Ingredient | BETAMETHASONE |
| Therapeutic Class | ADRENALS |
| Indications | Suppression of inflammatory and allergic disorders. |
| Caution | Adrenal suppression. Gastro Intestinal distress, euphoria/depression. |
| Dose Range | Adult: 0.5-5mg daily . |
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| Breast Feeding |
| Active Ingredient | DEFLAZACORT |
| Therapeutic Class | ADRENALS |
| Indications | |
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| Breast Feeding |
| Active Ingredient | DEXAMETHASONE |
| Therapeutic Class | ADRENALS |
| Indications |
Suppression of inflammatory and allergic disorders; shock; diagnosis of cushings disease. |
| Caution | See Betamethasone. |
| Dose Range |
Adult: 0.5-10mg daily in single or divided doses. Pediatric: 10- 100mcg/kg daily in 1-2 divided doses; (up to 300mcg/kg daily may be required in emergency situations). |
| Drug Interactions | |
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| Breast Feeding |
| Active Ingredient | DEXAMETHASONE SODIUM PHOSPHATE |
| Therapeutic Class | ADRENALS |
| Indications | Suppression of inflammatory and allergic disorders. |
| Caution | Adrenal suppression. Gastro Intestinal distress, euphoria/depression. |
| Dose Range |
Adult: i.m., slow i.v. injection or infusion 0.5-20mg. Pediatric: 200-500mg/kg daily . |
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| Breast Feeding |
| Active Ingredient | FLUDROCORTISONE |
| Therapeutic Class | ADRENALS |
| Indications | Mineralocorticoid replacement in adrenocortical insufficiency . |
| Caution | Edema, electrolyte abnormalities, growth suppression in children. |
| Dose Range |
Adult: 50-300mcg daily. Pediatric: Initially 50mcg-100mcg daily; maintenance 50-300mcg daily adjusted according to response. |
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| Breast Feeding |
| Active Ingredient | HYDROCORTISONE |
| Therapeutic Class | ADRENALS |
| Indications | For anti-inflammatory action, e.g. connective tissue disorders, chronic active hepatitis, allergic disorders. |
| Caution | Hypertension, sodium retention and potassium loss, diabetes, muscle weakness and myopathy , osteoporosis, mental changes, gastrointestinal upset and peptic ulcer; growth retardation in More ... |
| Dose Range | Adult: 20-30 mg daily in divided doses. Pediatric: 1 month to 18 yrs: initially 6-7 mg/m2 every 8 hours adjusted according to resp onse. Maintenance dose: 4-5 mg/m2 every 8 hours. |
| Drug Interactions | |
| Pregnancy | |
| Breast Feeding |