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Preparations Prescribing in Renal Disease Prescribing in Liver Disease
Active Ingredient ATRACURIUM
Therapeutic Class NEUROMUSCULAR BLOCKING AGENTS
Indications Neuromuscular blockade (short to intermediate duration) for surgery and intubation.
Caution Flushing; hypotension,Bronchospasm; hypersensitivity; skin reactions; tachycardia.
Dose Range Initially 300–600 micrograms/kg, then (by intravenous injection) 100–200 micrograms/kg as required, alternatively (by intravenous injection) initially 300–600 micrograms/kg, followed by (by intravenous infusion) 300–600 micrograms/kg/hour.
Drug Interactions
Pregnancy
Breast Feeding
Preparations (4) Prescribing in Renal Disease Prescribing in Liver Disease
Active Ingredient CISATRACURIUM
Therapeutic Class NEUROMUSCULAR BLOCKING AGENTS
Indications Neuromuscular blockade.
Caution Bradycardia.
Dose Range
Drug Interactions
Pregnancy
Breast Feeding Discontinue breastfeeding until the mother has recovered from neuromuscular bloc More ...
Preparations (3) Prescribing in Renal Disease Prescribing in Liver Disease
Active Ingredient PANCURONIUM BROMIDE
Therapeutic Class NEUROMUSCULAR BLOCKING AGENTS
Indications Usual drug of choice for major surgery and for use with long term ventilation of intensive care patients.
Caution Caution in hepatic and renal impairment. C.f. prescribing in renal
disease p. 34.
Dose Range i.v. 0.05-0.1mg/kg, then 0.01-0.02mg/kg as required.
Drug Interactions
Pregnancy
Breast Feeding Discontinue breastfeeding until the mother has recovered from neuromuscular bloc More ...
Preparations (2) Prescribing in Renal Disease Prescribing in Liver Disease (1)
Active Ingredient SUXAMETHONIUM
Therapeutic Class NEUROMUSCULAR BLOCKING AGENTS
Indications Depolarising muscle relaxant of short duration (about 5 mins). Useful for endotracheal intubation
Caution Tachycardia, apnoea, flushing.
Dose Range Adults and children: i.v. 0.5-2mg/kg dep ending on degree of
relaxation required. c.f. prescribing in liver disease p. 18.
Drug Interactions
Pregnancy Mildly prolonged maternal neuromuscular blockade may occur.
Breast Feeding Discontinue breastfeeding until the mother has recovered from neuromuscular bloc More ...
Preparations (4) Prescribing in Renal Disease Prescribing in Liver Disease
Active Ingredient TIZANIDINE
Therapeutic Class NEUROMUSCULAR BLOCKING AGENTS
Indications Spasticity associated with multiple sclerosis and cerebrovascular or spinal cord disorders.
Caution Drowsiness, muscle weakness, dry mouth, fatigue, insomnia, G.I. disturbances, dizziness.
Dose Range Adult: 2-4mg three times daily . Maximum dose is 36mg daily. Safety has not been determined in children.See BDS supply protocols pg. 11.
Drug Interactions
Pregnancy Avoid Tizanidine during pregnancy.
Breast Feeding Avoid breastfeeding during Tizanidine therapy.