| Active Ingredient | HYDRALLAZINE |
| Therapeutic Class | DIRECT VASODILATOR |
| Indications |
Moderate to severe hypertension. As a vasodilator decreasing afterload in intractable heart failure. To be used with a diuretic and beta blocker. |
| Caution | May cause angina in predisposed patients. Reversible SLE type syndrome with prolonged use of more than 200mg/day. Must be used with caution in patients on MAOI's or tricyclics. Severe headache, More ... |
| Dose Range |
Oral: 50-100mg daily in 2 divided doses. Inj: 5-10mg i.m. or i.v. by slow titration over 20-30 minutes or 200-300mcg/min by slow iv infusion. |
| Drug Interactions | |
| Pregnancy | Manufacturer advises that hydralazine should not be used before third trimester More ... |
| Breast Feeding | Use with caution as hydralazine is distributed into breastmilk but is not known More ... |
| Active Ingredient | MINOXIDIL |
| Therapeutic Class | DIRECT VASODILATOR |
| Indications | Severe hypertension unresponsive to standard therapy. Must be given with a beta blocker, and with a diuretic. |
| Caution | Potent vasodilator. May cause hirsutism and considerable oedema due to salt and water retention. |
| Dose Range |
Initially 5mg daily (elderly : 2.5mg) as a single or in divided doses gradually increased at 3 day intervals to 50mg daily. Maximum 100mg daily . |
| Drug Interactions | |
| Pregnancy | |
| Breast Feeding |