| Active Ingredient | CILASTATIN | IMIPENEM |
| Therapeutic Class | CARBAPENEMS |
| Indications |
Aerobic and anaerobic Gram-positive and Gram-negative infections; (not indicated for CNS infections) hospital-acquired septicaemia. |
| Caution |
Diarrhoea; eosinophilia; nausea (may reduce rate of infusion); rash; vomiting |
| Dose Range | Adult: 500mg every 6 hours, alternatively 1g every 8 hours. |
| Drug Interactions | |
| Pregnancy | Manufacturer advises avoid unless potential benefit outweighs risk. Both imipene More ... |
| Breast Feeding | Present in milk but unlikely to be absorbed. |
| Active Ingredient | ERTAPENEM |
| Therapeutic Class | CARBAPENEMS |
| Indications | |
| Caution | |
| Dose Range | |
| Drug Interactions | |
| Pregnancy | |
| Breast Feeding |
| Active Ingredient | MEROPENEM |
| Therapeutic Class | CARBAPENEMS |
| Indications | Indicated as a single agent therapy for the treatment of complicated skin and skin structure infections due to Staphylococcus aureus (methicillin-susceptible isolates only),Pseudomonas aeruginosa, Esc More ... |
| Caution |
Abdominal pain; diarrhoea; disturbances in liver function tests; headache; nausea; pruritus; rash; thrombocy thaemia; vomiting. |
| Dose Range | Adult: 0.5-1g every 8 hours |
| Drug Interactions | |
| Pregnancy | There are insufficient human data to establish whether there is a drug-associate More ... |
| Breast Feeding | Drug has been reported to be excreted in human milk; no information is available More ... |