| Active Ingredient | MACROLIDES |
| Therapeutic Class | MACROLIDES |
| Indications | |
| Caution | |
| Dose Range | |
| Drug Interactions | |
| Pregnancy | |
| Breast Feeding |
| Active Ingredient | ERYTHROMYCIN BASE |
| Therapeutic Class | ERYTHROMYCINS |
| Indications | Infections caused by most gram positive bacteria with limited usefulness in staphylococcal infections. Alternative to penicillin in hypertensive patients. Drug of choice for Legionnaires di More ... |
| Caution | Nausea, vomiting, abdominal cramps. C.f prescribing on liver and renal disease. P. 13 |
| Dose Range |
Adult: Stearate/Base: 250-500mg every 6 hours or 500mg every 12 hours to a maximum of 4g per day. May Take with food to lessen stomach upset. Injection15-2-mg /kg/day up to 4g/day. Pediatric: 1 month-2 years: 125mg four times a day; 2-8 years: 250mg f |
| Drug Interactions | |
| Pregnancy | |
| Breast Feeding | Only small amounts in milk—not known to be harmful. |
| Active Ingredient | ERYTHROMYCIN ESTOLATE |
| Therapeutic Class | ERYTHROMYCINS |
| Indications | Infections caused by most gram positive bacteria with limited usefulness in staphylococcal infections. Alternative to penicillin in hypertensive patients. Drug of choice for Legionnaires di More ... |
| Caution | Nausea, vomiting, abdominal cramps. C.f prescribing on liver and renal disease. P. 13 |
| Dose Range | Adult: Stearate/Base: 250-500mg every 6 hours or 500mg every 12 hours to a maximum of 4g per day. May Take with food to lessen stomach upset. Injection15-2-mg /kg/day up to 4g/day. Pediatric: 1 month-2 years: 125mg four times a day; 2-8 years: 250mg four |
| Drug Interactions | |
| Pregnancy | |
| Breast Feeding |
| Active Ingredient | ERYTHROMYCIN ETHYLSUCCINATE |
| Therapeutic Class | ERYTHROMYCINS |
| Indications | Infections caused by most gram positive bacteria with limited usefulness in staphylococcal infections. Alternative to penicillin in hypertensive patients. Drug of choice for Legionnaires disease. Chla More ... |
| Caution | Nausea, vomiting, abdominal cramps |
| Dose Range | Adult: Stearate/Base: 250-500mg every 6 hours or 500mg every 12 hours to a maximum of 4g per day. May Take with food to lessen stomach upset. Injection15-2-mg /kg/day up to 4g/day. Pediatric: 1 month-2 years: 125mg four times a day; 2-8 years: 250mg four |
| Drug Interactions | |
| Pregnancy | |
| Breast Feeding |
| Active Ingredient | ERYTHROMYCIN LACTOBIONATE |
| Therapeutic Class | ERYTHROMYCINS |
| Indications | Infections caused by most gram positive bacteria with limited usefulness in staphylococcal infections. Alternative to penicillin in hypertensive patients. Drug of choice for Legionnaires disease. Chla More ... |
| Caution | Nausea, vomiting, abdominal cramps |
| Dose Range | Adult: Stearate/Base: 250-500mg every 6 hours or 500mg every 12 hours to a maximum of 4g per day. May Take with food to lessen stomach upset. Injection15-2-mg /kg/day up to 4g/day. Pediatric: 1 month-2 years: 125mg four times a day; 2-8 years: 250mg four |
| Drug Interactions | |
| Pregnancy | |
| Breast Feeding |
| Active Ingredient | ERYTHROMYCIN STEARATE |
| Therapeutic Class | ERYTHROMYCINS |
| Indications | Infections caused by most gram positive bacteria with limited usefulness in staphylococcal infections. Alternative to penicillin in hypertensive patients. Drug of choice for Legionnaires disease. Chla More ... |
| Caution | Nausea, vomiting, abdominal cramps |
| Dose Range | Adult: Stearate/Base: 250-500mg every 6 hours or 500mg every 12 hours to a maximum of 4g per day. May Take with food to lessen stomach upset. Injection15-2-mg /kg/day up to 4g/day. Pediatric: 1 month-2 years: 125mg four times a day; 2-8 years: 250mg four |
| Drug Interactions | |
| Pregnancy | |
| Breast Feeding |
| Active Ingredient | AZITHROMYCIN |
| Therapeutic Class | OTHER MACROLIDES |
| Indications | Skin and soft tissue infections; respiratory tract infections, ottis media, uncomplicated genital chlamydia infections and non-gonococcal urethritis. |
| Caution | Gastrointestinal (abdominal pain, diarrhea and nausea), particularly with higher doses. Do not use with antacids. |
| Dose Range | Adult: 500mg daily for 3 day s or 500mg on first day then 250mg once daily for 4 days. Chancroid, Chlamydia: 1g stat dose. UncomplicatedGonorrhea: 2g stat dose. Pediatric: 6 months and over: 10mg/kg/day for 3 days. Tonsillitis: 2 years and over: 12mg/kg/ |
| Drug Interactions | |
| Pregnancy | Manufacturers advise use only if adequate alternatives are not available. |
| Breast Feeding | Present in milk; use only if there are no suitable alternatives. |
| Active Ingredient | CLARITHROMYCIN |
| Therapeutic Class | OTHER MACROLIDES |
| Indications |
Helicobacter pylori associated duodenal ulcers. Multiple-drug regimens have been used e.g. dual-drug (combination with omeprazole or ranitidine) ortriple-drug (combination with lansoprazole/ amoxicill More ... |
| Caution | Diarrhoea, nausea, vomiting or abdominal pain. Use with caution in patients with marked hepatic or renal impairment. May be taken with food to lessen stomach upset. Inform doctor if patient is taking More ... |
| Dose Range |
Adult: 250mg every 12 hours for 7 days, increased in severe infections to 500mg every 12 hours for up to 14 days. Pediatric: under 8kg: 7.5mg/kg twice daily ; 8-11kg (1-2 years); 62.5mg twice daily, 12-19kg (3-6 years) 125mg twice daily ; 20-29kg (7-9 |
| Drug Interactions | |
| Pregnancy | |
| Breast Feeding | Clarithromycin should be used with caution in nursing women since the drug is di More ... |
| Active Ingredient | ROXITHROMYCIN |
| Therapeutic Class | OTHER MACROLIDES |
| Indications | Nongonococcal urethritis, streptococcal pharyngitis, skin and soft tissue infections, upper and lower respiratory tract infections, otitis media. |
| Caution | Nausea, diarrhea, abdominal cramps and anorexia. The serum half-life of roxithromycin may increase in the presence of severe renal or hepatic failure, and dosage modification may be required. |
| Dose Range | Adult: 150mg twice a day or 300mg once daily . Pediatric: Usual doses are 2.5 to 5mg/kg every 12 hours. See BDS supply protocols pg.3. |
| Drug Interactions | |
| Pregnancy | |
| Breast Feeding |
| Active Ingredient | AMOXICILLIN |
| Therapeutic Class | PENICILLINS |
| Indications | Amoxicillin shares the uses of other aminopenicillins and is used principally for the treatment of infections caused by susceptible gram-negative bacteria (e.g., Haemophilus influenzae, Escherichia co More ... |
| Caution | Rashes, especially in infectious mono-nucleosis. Shake susp. well before taking dose. Liquid may be mixed with formula, milk, fruit juice, water or ginger ale and taken immediately. Must be taken for More ... |
| Dose Range | Adult: 250mg - 500mg 3 times daily. Pediatric: 1mth-1 yr: 62.5mg-125mg every 8 hours; 1yr-5 yrs: 125mg every 8 hours; from 5 yrs; 250mgevery 8 hours. |
| Drug Interactions | |
| Pregnancy | Not known to be harmful. |
| Breast Feeding | Trace amount in milk, but appropriate to use. |
| Active Ingredient | AMOXICILLIN | CLAVULANIC ACID |
| Therapeutic Class | PENICILLINS |
| Indications | Infections due to beta-lactamase-producing strains where amoxicillin alone is not appropriate. |
| Caution | Hepatitis; nausea; vomiting, risk of cholestatic jaundice, hence treatment should not usually exceed 14 days. |
| Dose Range | Calculated on amoxicillin content, similar to those for amoxicillin used alone. |
| Drug Interactions | |
| Pregnancy | |
| Breast Feeding | Because amoxicillin and clavulanic acid are distributed into milk, amoxicillin a More ... |
| Active Ingredient | AMPICILLIN |
| Therapeutic Class | PENICILLINS |
| Indications | For infections caused by H. influenzae and Strep. moniae and any other susceptible organisms. However, please note that the oral forms have been replaced by amoxicillin. |
| Caution |
Erythema multiforme, Exfoliative dermatitis, rash , urticaria , fever , seizure, diarrhea, black hairy tongue, nausea, oral candidiasis, vomiting, Use caution in allergy to cephalosporins, carbapenem More ... |
| Dose Range | Adult: 500mg-1g every 4-6 hours. Pediatric: 25-50mg/kg/day in divided doses every 4-12 hours; maximum 2g every 4 hours. |
| Drug Interactions | |
| Pregnancy | Pregnancy category: B. B: May be acceptable. Either animal studies show no risk More ... |
| Breast Feeding | Trace amounts in milk, but appropriate to use. |
| Active Ingredient | CLOXACILLIN |
| Therapeutic Class | PENICILLINS |
| Indications | Infections caused by penicillin resistant staphylocci. |
| Caution | As for penicillin G. Oral absorption is complete. Take on empty stomach. |
| Dose Range |
Adult: 500mg every 6 hours. Pediatric 1 mth and over: 50- 100mg/kg/day every 6 hours;orally. See BDS supply protocols pg. 3. |
| Drug Interactions | |
| Pregnancy | |
| Breast Feeding |
| Active Ingredient | PENICILLIN G BENZATHINE |
| Therapeutic Class | PENICILLINS |
| Indications | Streptococcal infections, diphtheria (asymptomatic carriers), pharyngitis, syphilis, primary and secondary prophylaxis of rheumaticfever. |
| Caution | History of allergy, hypersensitivity. Urticaria, joint pains, fever, angioneurotic odema. Anaphylactic shock, hemolytic anemia, exfoliative dermatitis. |
| Dose Range | 300,000-1.2 million units/day divided every 3-4 hours. |
| Drug Interactions | |
| Pregnancy | |
| Breast Feeding |
| Active Ingredient | PENICILLIN G SODIUM |
| Therapeutic Class | PENICILLINS |
| Indications | Tonsillitis, otitis media, erysipelas, streptococcal endocarditis, meningococcal and pneumococcal meningitis. Prophylaxis in limb amputation. |
| Caution |
History of allergy and hypersensitivity. Urticaria, joint pains, fever, angioneurotic oedema, anaphylactic shock, diarrhoea. Renal impairment. C.f. prescribing in renal disease p. 23. |
| Dose Range |
i.m or slow i.v: 0.6 to 4.8g daily in 4-6 divided doses.Severe infections e.g endocarditis, 7.2g daily (1.2g every 4hours) intravenously, usually with an aminogly coside. Meningococcal and pneumococcal meningitis, 14.4g daily (2.4g every 4 hours) intraven |
| Drug Interactions | |
| Pregnancy | |
| Breast Feeding |
| Active Ingredient | PENICILLIN V |
| Therapeutic Class | PENICILLINS |
| Indications | For the treatment of Streptococcal Pharyngitis,Periodontal Infections, Recurrent Rheumatic Fever, |
| Caution |
.Diarrhea, Nausea,Oral candidiasis, vomiting , seizure , anemia, Positive Coombs reaction. May decrease the effectiveness of birth control pill. |
| Dose Range | Adult and children 12 years and over: 250-500mg every 6 hours. Up to 1g in severe infections. Pediatric: 1 month-1 year: 62.5mg every 6 hours. 1-5 years: 125mg every 6 hours. 6-12 years 250mg every 6 hours. See BDS supply protocols pg. 3. |
| Drug Interactions | |
| Pregnancy | |
| Breast Feeding |
| Active Ingredient | PIPERACILLIN | TAZOBACTAM |
| Therapeutic Class | PENICILLINS |
| Indications | Moderate to severe infections caused by lactamase producing isolates of Staphylococcus aureus, isolates of H influenzae and isolates of E coli bacteria. |
| Caution | Nausea, vomiting. Constipation, headache , fever, oral candidiasis, rash, pruritis, dyspepsia, hypertension |
| Dose Range | 4.5g every 8 hours or 3.375g every 6 hours |
| Drug Interactions | |
| Pregnancy | |
| Breast Feeding | Trace amount in milk, but appropriate to use. |
| Active Ingredient | CIPROFLOXACIN |
| Therapeutic Class | QUINOLONES |
| Indications |
Ciprofloxacin is effective in a variety of infections due to gram- positive and gram-negative pathogens, including multi-resistant strains. It is also indicated for us in individuals exposed to inha More ... |
| Caution | Gastrointestinal disturbances; CNS side effects, including seizures. Increases in transaminases and in some cases severe and fatal hepatitis have developed. Hematuria and anaphylactic reactions have More ... |
| Dose Range | Adult: 250-750mg twice daily, depending on the severity of the infection. Inhalational post-exposure anthrax: 500mg every 12 hours. Pediatric: inhalational p ost-exposure anthrax: 10mg/kg every 12 hours. Maximum 400mg daily. See BDS supply protocols |
| Drug Interactions | |
| Pregnancy | Avoid in pregnancy—shown to cause arthropathy in animal studies; safer alternati More ... |
| Breast Feeding | Amount too small to be harmful but manufacturer advises avoid. |
| Active Ingredient | LEVOFLOXACIN |
| Therapeutic Class | QUINOLONES |
| Indications | Community -acquired pneumonia, urinary -tract infections, chronic prostatitis, complicated skin and soft tissue infections. |
| Caution | Constipation; flatulence (in adults); hyperhidrosis (in adults). The drug should be discontinued if psychiatric, neurological, or hypersensitivity reactions (including severe rash) occur. |
| Dose Range | Adult: 250 to 500 mg once or twice daily for 7 to 14 days depending on the severity and nature of the infection. Chronic prostatitis: 500mg once daily for 28 days. |
| Drug Interactions | |
| Pregnancy | Avoid in pregnancy—shown to cause arthropathy in animal studies; safer alternati More ... |
| Breast Feeding | Manufacturer advises use only if potential benefit outweighs risk. |
| Active Ingredient | MOXIFLOXACIN |
| Therapeutic Class | QUINOLONES |
| Indications | Bacterial conjunctivitis. |
| Caution | Taste disturbances, ocular discomfort, irritation and dryness, hyperaemia, photophobia, visual disturbances and nasal discomfort. |
| Dose Range |
Adult and child over 1 month: 3 times daily, continue treatment for 2-3 days after infection improves. |
| Drug Interactions | |
| Pregnancy | Avoid in pregnancy—shown to cause arthropathy in animal studies; safer alternati More ... |
| Breast Feeding |