Active Ingredient | CEFAZOLIN |
Therapeutic Class | FIRST GEN CEPHALOSPORINS |
Indications | Infections due to susceptible Gram-positive and Gram-negative bacteria. |
Caution |
Anorexia, Diarrhea , Eosinophilia , Fever ,Increased transaminases Leukopenia ,Nausea and vomiting ,Neutropenia ,Oral candidiasis,Pain at injection site ,Phlebitis |
Dose Range |
Adult: 500mg-1g every 8 hours with up to 1-1.5g every 6 hours in severe infections. Pediatric: 25-50mg/kg/day in 3-4 doses up to 100mg/kg/day . |
Drug Interactions | |
Pregnancy | |
Breast Feeding |
Active Ingredient | CEPHRADINE |
Therapeutic Class | FIRST GEN CEPHALOSPORINS |
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Breast Feeding |
Active Ingredient | CEFUROXIME |
Therapeutic Class | SECOND GEN CEPHALOSPORINS |
Indications | Infections caused by susceptible Gram-positive and Gram-negative bacteria, including infections of the bones and joints, CNS, skin and skin structures, respiratory tract, genito-urinary tract (includi More ... |
Caution | Gastrointestinal disturbances, including diarrhoea, nausea, and vomiting. Mild to moderate hearing loss has been reported in some children given cefuroxime for the treatment of meningitis. |
Dose Range | Adult and children 12 years and over: 250 mg twice daily dose may be doubled in severe lower respiratory tract infections or if pneumonia is suspected; Pediatric: 3 months–2 years; 10 mg/kg twice daily (max. p er dose 125 mg). 2–11 years; 15 mg/kg twice |
Drug Interactions | |
Pregnancy | |
Breast Feeding | Present in milk in low concentration, but appropriate to use. |
Active Ingredient | CEFIXIME |
Therapeutic Class | THIRD GEN CEPHALOSPORINS |
Indications | |
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Dose Range | |
Drug Interactions | |
Pregnancy | |
Breast Feeding |
Active Ingredient | CEFOTAXIME |
Therapeutic Class | THIRD GEN CEPHALOSPORINS |
Indications | Infections due to susceptible Gram-positive and Gram-negative bacteria, surgical infection prophylaxis, uncomplicated gonorrhea. |
Caution | Colitis ,Diarrhea ,Elevated blood urea nitrogen (BUN) and creatinine ,Elevated hepatic transaminases ,Eosinophilia ,Fever ,Injection site pain , Nausea ,Pruritus ,Rash |
Dose Range |
Adult: 1g every 12 hours. gonorrhoea; 500mg i.m. Pediatric: Child 1 month–11 years: 50mg/kg every 12 hours; Child 12–17 years; 1g every 12 hours. |
Drug Interactions | |
Pregnancy | |
Breast Feeding | Present in milk in low concentration, but appropriate to use. |
Active Ingredient | CEFTAZIDIME |
Therapeutic Class | THIRD GEN CEPHALOSPORINS |
Indications | Infections caused by susceptible Gram-positive and Gram-negative bacteria, especially infections due to Pseudomonas spp . |
Caution | Transient increases in transaminases, eosinophilia, diarrhea, immune hypersensitivity reaction, phlebitis, rash (maculopapular or erythematous), thrombocytosis, injection site pain, abdominal pain |
Dose Range | Adult:1g every 8-12 hours. Maximum 6g daily . |
Drug Interactions | |
Pregnancy | |
Breast Feeding | Present in milk in low concentration, but appropriate to use. |
Active Ingredient | CEFTRIAXONE |
Therapeutic Class | THIRD GEN CEPHALOSPORINS |
Indications | As for Cephadroxil |
Caution | As for Cephadroxil |
Dose Range | 1-2g once daily or in two divided doses. Maxiumum 4g daily. |
Drug Interactions | |
Pregnancy | Specialist sources indicate suitable for use in pregnancy. |
Breast Feeding | Present in milk in low concentration, but appropriate to use. |
Active Ingredient | CEFEPIME |
Therapeutic Class | FOURTH GEN CEPHALOSPORINS |
Indications | Infections due to susceptible Gram-positive and Gram-negative bacteria, including those of the abdomen, urinary tract, respiratory tract, and skin and skin structures. Effective against Pseudomonas a More ... |
Caution | Hypersensitivity reactions. |
Dose Range | Adult: 1 to 2g daily in 2 divided doses for mild to moderate infections, increased to 4g daily in 2 divided doses in severe infections. Maximum 6g daily. |
Drug Interactions | |
Pregnancy | |
Breast Feeding | Cefepime is distributed into milk in low concentrations following parenteral adm More ... |
Active Ingredient | CILASTATIN | IMIPENEM |
Therapeutic Class | CARBAPENEMS |
Indications |
Aerobic and anaerobic Gram-positive and Gram-negative infections; (not indicated for CNS infections) hospital-acquired septicaemia. |
Caution |
Diarrhoea; eosinophilia; nausea (may reduce rate of infusion); rash; vomiting |
Dose Range | Adult: 500mg every 6 hours, alternatively 1g every 8 hours. |
Drug Interactions | |
Pregnancy | Manufacturer advises avoid unless potential benefit outweighs risk. Both imipene More ... |
Breast Feeding | Present in milk but unlikely to be absorbed. |
Active Ingredient | ERTAPENEM |
Therapeutic Class | CARBAPENEMS |
Indications | |
Caution | |
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Pregnancy | |
Breast Feeding |
Active Ingredient | MEROPENEM |
Therapeutic Class | CARBAPENEMS |
Indications | Indicated as a single agent therapy for the treatment of complicated skin and skin structure infections due to Staphylococcus aureus (methicillin-susceptible isolates only),Pseudomonas aeruginosa, Esc More ... |
Caution |
Abdominal pain; diarrhoea; disturbances in liver function tests; headache; nausea; pruritus; rash; thrombocy thaemia; vomiting. |
Dose Range | Adult: 0.5-1g every 8 hours |
Drug Interactions | |
Pregnancy | There are insufficient human data to establish whether there is a drug-associate More ... |
Breast Feeding | Drug has been reported to be excreted in human milk; no information is available More ... |
Active Ingredient | MACROLIDES |
Therapeutic Class | MACROLIDES |
Indications | |
Caution | |
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Pregnancy | |
Breast Feeding |
Active Ingredient | ERYTHROMYCIN BASE |
Therapeutic Class | ERYTHROMYCINS |
Indications | Infections caused by most gram positive bacteria with limited usefulness in staphylococcal infections. Alternative to penicillin in hypertensive patients. Drug of choice for Legionnaires di More ... |
Caution | Nausea, vomiting, abdominal cramps. C.f prescribing on liver and renal disease. P. 13 |
Dose Range |
Adult: Stearate/Base: 250-500mg every 6 hours or 500mg every 12 hours to a maximum of 4g per day. May Take with food to lessen stomach upset. Injection15-2-mg /kg/day up to 4g/day. Pediatric: 1 month-2 years: 125mg four times a day; 2-8 years: 250mg f |
Drug Interactions | |
Pregnancy | |
Breast Feeding | Only small amounts in milk—not known to be harmful. |
Active Ingredient | ERYTHROMYCIN ESTOLATE |
Therapeutic Class | ERYTHROMYCINS |
Indications | Infections caused by most gram positive bacteria with limited usefulness in staphylococcal infections. Alternative to penicillin in hypertensive patients. Drug of choice for Legionnaires di More ... |
Caution | Nausea, vomiting, abdominal cramps. C.f prescribing on liver and renal disease. P. 13 |
Dose Range | Adult: Stearate/Base: 250-500mg every 6 hours or 500mg every 12 hours to a maximum of 4g per day. May Take with food to lessen stomach upset. Injection15-2-mg /kg/day up to 4g/day. Pediatric: 1 month-2 years: 125mg four times a day; 2-8 years: 250mg four |
Drug Interactions | |
Pregnancy | |
Breast Feeding |
Active Ingredient | ERYTHROMYCIN ETHYLSUCCINATE |
Therapeutic Class | ERYTHROMYCINS |
Indications | Infections caused by most gram positive bacteria with limited usefulness in staphylococcal infections. Alternative to penicillin in hypertensive patients. Drug of choice for Legionnaires disease. Chla More ... |
Caution | Nausea, vomiting, abdominal cramps |
Dose Range | Adult: Stearate/Base: 250-500mg every 6 hours or 500mg every 12 hours to a maximum of 4g per day. May Take with food to lessen stomach upset. Injection15-2-mg /kg/day up to 4g/day. Pediatric: 1 month-2 years: 125mg four times a day; 2-8 years: 250mg four |
Drug Interactions | |
Pregnancy | |
Breast Feeding |
Active Ingredient | ERYTHROMYCIN LACTOBIONATE |
Therapeutic Class | ERYTHROMYCINS |
Indications | Infections caused by most gram positive bacteria with limited usefulness in staphylococcal infections. Alternative to penicillin in hypertensive patients. Drug of choice for Legionnaires disease. Chla More ... |
Caution | Nausea, vomiting, abdominal cramps |
Dose Range | Adult: Stearate/Base: 250-500mg every 6 hours or 500mg every 12 hours to a maximum of 4g per day. May Take with food to lessen stomach upset. Injection15-2-mg /kg/day up to 4g/day. Pediatric: 1 month-2 years: 125mg four times a day; 2-8 years: 250mg four |
Drug Interactions | |
Pregnancy | |
Breast Feeding |
Active Ingredient | ERYTHROMYCIN STEARATE |
Therapeutic Class | ERYTHROMYCINS |
Indications | Infections caused by most gram positive bacteria with limited usefulness in staphylococcal infections. Alternative to penicillin in hypertensive patients. Drug of choice for Legionnaires disease. Chla More ... |
Caution | Nausea, vomiting, abdominal cramps |
Dose Range | Adult: Stearate/Base: 250-500mg every 6 hours or 500mg every 12 hours to a maximum of 4g per day. May Take with food to lessen stomach upset. Injection15-2-mg /kg/day up to 4g/day. Pediatric: 1 month-2 years: 125mg four times a day; 2-8 years: 250mg four |
Drug Interactions | |
Pregnancy | |
Breast Feeding |
Active Ingredient | AZITHROMYCIN |
Therapeutic Class | OTHER MACROLIDES |
Indications | Skin and soft tissue infections; respiratory tract infections, ottis media, uncomplicated genital chlamydia infections and non-gonococcal urethritis. |
Caution | Gastrointestinal (abdominal pain, diarrhea and nausea), particularly with higher doses. Do not use with antacids. |
Dose Range | Adult: 500mg daily for 3 day s or 500mg on first day then 250mg once daily for 4 days. Chancroid, Chlamydia: 1g stat dose. UncomplicatedGonorrhea: 2g stat dose. Pediatric: 6 months and over: 10mg/kg/day for 3 days. Tonsillitis: 2 years and over: 12mg/kg/ |
Drug Interactions | |
Pregnancy | Manufacturers advise use only if adequate alternatives are not available. |
Breast Feeding | Present in milk; use only if there are no suitable alternatives. |
Active Ingredient | CLARITHROMYCIN |
Therapeutic Class | OTHER MACROLIDES |
Indications |
Helicobacter pylori associated duodenal ulcers. Multiple-drug regimens have been used e.g. dual-drug (combination with omeprazole or ranitidine) ortriple-drug (combination with lansoprazole/ amoxicill More ... |
Caution | Diarrhoea, nausea, vomiting or abdominal pain. Use with caution in patients with marked hepatic or renal impairment. May be taken with food to lessen stomach upset. Inform doctor if patient is taking More ... |
Dose Range |
Adult: 250mg every 12 hours for 7 days, increased in severe infections to 500mg every 12 hours for up to 14 days. Pediatric: under 8kg: 7.5mg/kg twice daily ; 8-11kg (1-2 years); 62.5mg twice daily, 12-19kg (3-6 years) 125mg twice daily ; 20-29kg (7-9 |
Drug Interactions | |
Pregnancy | |
Breast Feeding | Clarithromycin should be used with caution in nursing women since the drug is di More ... |
Active Ingredient | ROXITHROMYCIN |
Therapeutic Class | OTHER MACROLIDES |
Indications | Nongonococcal urethritis, streptococcal pharyngitis, skin and soft tissue infections, upper and lower respiratory tract infections, otitis media. |
Caution | Nausea, diarrhea, abdominal cramps and anorexia. The serum half-life of roxithromycin may increase in the presence of severe renal or hepatic failure, and dosage modification may be required. |
Dose Range | Adult: 150mg twice a day or 300mg once daily . Pediatric: Usual doses are 2.5 to 5mg/kg every 12 hours. See BDS supply protocols pg.3. |
Drug Interactions | |
Pregnancy | |
Breast Feeding |