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| Active Ingredient | PYRAZINAMIDE |
| Therapeutic Class | ANTITUBERCULOSIS AGENTS |
| Indications | Tuberculosis as a second line drug in combination with other drugs. |
| Caution | Hyperuricemia, acute gout, hepatotoxicity, G.I. upset. Diabetes mellitus becomes more difficult to manage. Monitor SGOT, SGPT and uric acid levels. Give intermittently to avoid hypercalcaemia. |
| Dose Range | 15-30 mg/kg/day up to a max.of 2 g daily ; or 50-70 mg/kg 2-3 times weekly. Tuberculosis in AIDS p atients, doses of 20 to 30mg/kg/day have been successful. Dosage reduction is recommended in patients with endstage renal disease. Take with food to avoid |
| Drug Interactions | |
| Pregnancy | |
| Breast Feeding | Because pyrazinamide is distributed into milk in small amounts, a decision shoul More ... |