Formulary Monographs [PYRAZINAMIDE, 081604]
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PYRAZINAMIDE
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ANTITUBERCULOSIS AGENTS
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Tuberculosis as a second line drug in combination with other drugs.
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Hyperuricemia, acute gout, hepatotoxicity, G.I. upset. Diabetes mellitus becomes more difficult to manage. Monitor SGOT, SGPT and uric acid levels. Give intermittently to avoid hypercalcaemia.
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15-30 mg/kg/day up to a max.of 2 g daily ; or 50-70 mg/kg 2-3 times weekly. Tuberculosis in AIDS p atients, doses of 20 to 30mg/kg/day have been successful. Dosage reduction is recommended in patients with endstage renal disease. Take with food to avoid
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Because pyrazinamide is distributed into milk in small amounts, a decision should be made whether to discontinue nursing or the drug, taking into account the importance of the drug to the woman.
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