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Preparations (2) Prescribing in Renal Disease (1) Prescribing in Liver Disease
Active Ingredient MELPHALAN
Therapeutic Class ANTINEOPLASTICS
Indications Breast cancer, multiple myeloma
Caution Anorexia, nausea and vomiting, leukopenia, thrombocytopenia and
anaemia.
Severe bone marrow suppression with resulting infection or bleeding may occur.
Dose Range Breast Cancer: 150mcg/kg daily in divided doses for 5 days repeated every 6 weeks. Multiple Myeloma: 6mg daily for 2-3 weeks with with rest periods of up to 6 weeks.
Drug Interactions
Pregnancy Therapy may suppress ovarian function and result in amenorrhea
Breast Feeding Not recommended during therapy.