Rx Name [ZUCLOPENTHIXOL, 28160832]

Rx Name	CLOPIXOL 10MG TAB (LUN/COL) ZUCLOPENTHIXOL
Active Ingredient	ZUCLOPENTHIXOL
Therapeutic Code	28160832
Therapeutic Class	THIOXANTHENES
Indications
Caution
Dose Range
Drug Interactions
Pregnancy
Breast Feeding
Drug Note	Cardiac Glycosides These have a positive inotropic effect and reduce the size of a failing dilated heart leading to increased cardiac output and increased efficiency. They increase myocardial excit-ability and automaticity, depress conducting tissue and increase vagal activity. Digoxin’s half-life is more than 24 hours. The therapeutic blood level is 0.8 to 2.0mg/ml. General Indications (Digoxin) Cardiac failure, atrial fibrillation, atrial flutter, paroxysmal atrial tachcardia. Cautions/Side Effects (Digoxin) These usually occur at toxic serum levels above 2.0 mg/ml, but may do so in the therapeutic range especially in the elderly. Fatigue, anorexia, nausea, visual disturbances, muscle weakness, psychic symptoms, abdominal pain, dizziness, vomiting, cardiacdisturbance - heart block,cardiac arrhythmias. Tocicity most likely with hypokalemia. Treat digoxin - induced heart block with atropine; PVC’s and ventricular tachycardia with i.v. phenytoin. These drugs must be used with caution: (1) following acute myocar-dial infarction; (2) within 14 days of previous treatment with cardiac glycosides; (3) in the presence of Quinidine treatment; (4) in the presence of severe potassium imbalance; (5) in renal insufficiency and in the elderly (most of whom have some renal impairment). Dose Range (Digoxin) Loading dose 0.75 - 1.5mg in first day (e.g. 0.5mg initially and 0.25mg every 6 - 8 hours until desirable effect is reached or toxicity occurs). Maintenance dose 0.125 - 0.25mg. Children - oral: 25 - 35 mcg/kg every 6 hours until digitalization, then 25 - 35% of loading dose for maintenance. Anti-Arrhythmics The physiology of arrhythmias is complex and the action of drugs used in their treatment equally so. CLASS I - Membrane stabilizers CLASS II - Drugs which reduce sym-pathetic activity CLASS III - Drugs which prolong the effective refractory period and duration of the action potential CLASS IV - Drugs which interfere with calcium transfer into the cell

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