Rx Name [WARFARIN, 20120408]
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APO-WARFARIN 1MG TAB (APO/COL)
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20120408
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COUMARIN DERIVATIVES
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Prophylaxis and treatment of venous thrombus and its extension. Also see information on anticoagulants on p. 186.
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Haemorrhage. Prothrombin times should be determined daily at start of therapy. The following drugs may delay coagulation or increase prothombin time. Aspirin, phenylbutazone, tamoxifen, indomethacin, dipyridamole, clofibrate and barbiturates. Avoid use with Gingko Biloba, garlic, St. John’s Wort and Papaya, green leafy vegetables, soya products.
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2-10mg daily for maintenance.
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Should not be given in pregnancy. Warfarin crosses the placenta with risk of congenital malformations, and placental, fetal, or neonatal haemorrhage, especially during the last few weeks of pregnancy and at delivery.
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Warfarin is not distributed in breastmilk.
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