Rx Name [RIFAMPICIN, 081604]
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RIFAMPICIN 150MG CAP (MCP/AHI)
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081604
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ANTITUBERCULOSIS AGENTS
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Tuberculosis, in combination with other drugs.
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Orange coloured urine, tears and saliva. Flu-like syndrome, hepatitis, thrombocytopenia, hemolysis, renal failure. Monitor SGOT, SGPT levels and discontinue if levels are more than twice normal. Check platelet count if suspected. May reduce effectiveness of the contraceptive pill. Avoid alcohol while taking this medication.Take medication on an empty stomach. Soft contact lenses may be permanently stained by Rifampicin. Do not wear while taking this medication. C.f. prescribing in liver disease p. 17.
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Adult: 600mg/day . Pediatric: 10-20mg/kg/day, up to a maximum of
600 mg/day. The duration of therapy varies with the infection or condition being treated. Dosage adjustments should be considered in patients with liver disease. Take at least 30 minutes |
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The treatment of tuberclosis can be divided into two phases, an initial phase where three drugs are used and a second or continious phase, where two drugs are used. The recommended regime is an initial phase of Isonaizid , Rifampicin and other Streptomycin or Ethambutol for two omnths and the continuation phase of Isonaizid and Rifampicin for seven months, i.e. a total treatent time of nine months. Isoniazid is still con-sidered to be the primary drug for chemotherapy of tuber-culosis.
Cautions/Side Effects Patients on long term Isoniazid should be given Pyridoxine Hydrochloride prophylactically. Rifampicin is a potent inducer of liver enzymes and may provide important interactions with other drugs. (see p. 42). |