Rx Name [HYDROXYUREA, 1000]

Rx Name	APO-HYDROXYUREA 500MG CAP (APO/COL)
Active Ingredient	HYDROXYUREA
Therapeutic Code	1000
Therapeutic Class	ANTINEOPLASTICS
Indications	Chronic myeloid leukemia.
Caution	Anorexia, nausea and vomiting, stomatitis, leukopenia, thrombocytopenia and anaemia-less marked than leukopenia, megaloblastosis, alopecia is rare. Directly inhibits DNA synthesis primarily by inhibition of ribonucleoside diphosphate reductase. Take on an empty stomach. Maintain ample fluid intake. Avoid alcohol.
Dose Range	20-30mg/kg/day administered as a single dose.
Drug Interactions
Pregnancy	Hydroxyurea can cause fetal toxicity when administered to pregnant women, but potential benefits from use of the drug may be acceptable in certain conditions despite the possible risks to the fetus.
Breast Feeding	Hydroxyurea is distributed into milk. Breastfeeding is not recommended during hydroxyurea therapy.
Drug Note