Formulary Monographs [SULPHASALAZINE, 081220]
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SULPHASALAZINE
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SULPHONAMIDES
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Inflammatory bowel disease.
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Yellow-orange discoloration of skin, urine and other body fluids. Increased sensitivity to sunlight. Do not take if allergic to sulfa-drugs, aspirin or other salicyclates. Take with food to avoid stomach up set. Drink with a full glass of water. Drink several glasses of water every day during therapy . C.f. prescribing in renal disease p. 37.
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Adult: 1-2g 4 times daily. Maintenance: 500mg 4 times a day. Pediatric: 2 years and older: 40-60mg/kg daily. Maintenance: 20-30mg/kg daily .
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Theoretical risk of neonatal haemolysis in
third trimester; adequate folate supplements should be given to mother. |
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Small amounts in milk (1 report of
bloody diarrhoea); theoretical risk of neonatal haemolysis especially in G6PD-deficient infants. |
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