Formulary Monographs [SULFAMETHOXAZOLE|TRIMETHOPRIM, 081220]
|
|
SULFAMETHOXAZOLE | TRIMETHOPRIM
|
|
|
|
|
|
SULPHONAMIDES
|
|
|
Urinary tract infections; typhoid, invasive Salmonellosis; H. influenzae. Infections, exacerbations of chronic bronchitis.
|
|
|
Discontinue if skin rash develops. Nausea and vomiting may occur. Sensitivity to sunlight increases while taking this medication. Use a sunscreen when outdoors. C.f. prescribing in renal disease p. 27.
|
|
|
Adult: 1-2 tablets every 8-12 hours. Pediatric: 6 weeks - 5 months: ½
teaspoonful every 12 hours. 6 months - 5 years: 1 teaspoonful every 12 hours. 6-12 years: 2 teaspoonsful every 12 hours. Take with a full glass of water and drink several glasses of wat |
|
|
|
|
|
Co-trimoxazole crosses the placenta and may interfere with folic acid metabolism. Should be used during pregnancy only when the potential benefits justify the possible risks to the fetus.
|
|
|
Co-trimoxazole is distributed into milk with small risk of kernicterus in jaundiced infants and of haemolysis in G6PD-deficient infants (due to sulfamethoxazole).
|
|
|
|