Formulary Monographs [STAVUDINE, 08180820]
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STAVUDINE
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NRTI
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Adult and Children 12 years and over: One tablet twice daily (150mg lamivudine/300mg zidovudine p er tablet). Not recommended in children under 12 y ears.
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Peripheral neuropathy , serum transaminase elevations, lactic acidosis and severe hepatomegaly with steatosis including fatal cases have been reported. Concurrent administration of stavudine and hydroxy -urea or didanosine can result in fatal pancreatitis and hepatotoxicity . St. John’s wort causes decreased stavudine concentration which may lead to antiviral resistance.
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Adult greater than 60kg: 40mg every 12 hours and less than 60kg:
30mg every 12 hours. Pediatric: birth to 13 days: 0.5 mg/kg every 12 hours. 14 days and older: 1 mg/kg every 12 hours and weighing less than 30 kg. May be taken without regard to meals. |
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The Centers for Disease Control and Prevention (CDC) and other experts recommend that HIV-infected women not breast-feed infants, regardless of antiretroviral therapy due to the risk of transmitting the virus through breastfeeding.
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