Formulary Monographs [PRIMIDONE, 281204]
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PRIMIDONE
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BARBITURATES (ANTICONVULSANTS)
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As for phenytoin, but no longer recommended except for patients already well controlled with it.
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Avoid sudden withdrawal. Drowsiness, ataxia, nausea, rashes and folate deficiency. May decrease effectiveness of pill, may cause drowsiness and loss of appetite. Avoid alcohol. C.f. prescribing in liver and renal disease p. 16; 35.
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Adult and children 10 years and over: 125mg at bedtime increased if necessary by 125mg every 3 days to a total of 500mg daily in divided doses. The daily dose may be increased further every 3 days by 250 mg up to a maximum of 1.5 g daily given in divided
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