Formulary Monographs [PHYTOMENADIONE, 8824]
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PHYTOMENADIONE
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VITAMIN K ACTIVITY
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Vitamin K deficiency most commonly seen in hepatic failure. Overdose of oral anticoagulant.
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Vitamin K antagonises the anticoagulant effects of coumarins and indandiones. Antibiotics in the gut may reduce or inhibit the bacterial sy nthesis of vitamin K.
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In the treatment of vitamin K deficiency bleeding in neonates, 1 mg intravenously, subcutaneously, or intramuscularly; further doses maybe given if necessary. As a prophylactic measure, a single dose of 0.5 to 1 mg may be given intramuscularly to the newb
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