Formulary Monographs [MINOCYCLINE, 081224]
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MINOCYCLINE
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TETRACYCLINES
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Meningococcal carriers. Active against N. Meningitidis, some Methicillin Resistant Staph & H. Influenzae. Urinary and respiratory tract infections, acne and skin and soft tissue infections.
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G.I upset, vestibular dysfunction, headache, localized pigmentary disturbances.Not to be used in children under 8 years. C.f. prescribing in liver and renal disease p. 15; 32.
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Adult and Children 12 years and over: 200mg followed by 100mg every 12 hours. Do not exceed 400mg in 24 hours. See BDS supply protocols pg. 3.
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Avoid in pregnant women. Administration during the second or third trimester may cause discoloration of the child’s teeth, and maternal hepatotoxicity has been reported with large parenteral doses.
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Tetracyclines are excreted in breastmilk and cross the
placenta. Consequently they chelate with calcium in the fetus and infant leading to damage to growing bones & teeth. |
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