Formulary Monographs [METRONIDAZOLE, 083092]
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METRONIDAZOLE
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ANTIPROTOZOALS, MISCELLANEOUS
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Metronidazole is an antimicrobial drug with high activity against anaerobic bacteria and protozoa.
Trichomonas vaginalis. Giardia lambia, Entamoeba histolytica. Active against anaerobic bacteria and protozoa. Surgical and gynaecological sepsis especially B. fragilis. |
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May be taken with food or milk to avoid stomach upset. May turn urine a reddish-brown colour.
For topical use; avoid exposure to strong sunlight or UV light. Common Side effects seen with oral use- Agranulocytosis; ataxia; cerebellar syndrome; confusion; dizziness; drowsiness; encephalopathy; flushing; hallucination; headache; hepatic disorders; myalgia; neutropenia; pancreatitis; pancytopenia; psychotic disorder; seizure; severe cutaneous adverse reactions (SCARs); skin reactions; thrombocytopenia; |
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Adult: 400mg every 8 hours for 7 days or 500g every 8 hours ; 800mg in the morning and
1.2g at night; or a single 2g dose. i.v (see category B): Pediatric: 7.5mg/kg every 8 hours. Vaginal gel: One applicatorful once or twice daily for 5 day s. |
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Avoid alcohol while taking this drug. The manufacturers recommend that alcohol not be consumed during or for at least 1 day (or at least 3 days with the oral capsules or extended-release oral tablets) following completion of metronidazole therapy
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Use with caution. With systemic use:
Manufacturer advises avoidance of high-dose regimens; use only if potential benefit outweighs risk. |
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Use with caution as therapeutic levels can be found in breastmilk and will produce an unpleasant taste of the breast milk.
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