Formulary Monographs [LAMIVUDINE|ZIDOVUDINE, 08180892]
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LAMIVUDINE | ZIDOVUDINE
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ANTIRETROVIRALS MISCELLANEOUS
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Indicated in combination with other antiretroviral agents for the treatment of HIV infection.
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Headache, fatigue, nausea, vomiting, diarrhoea, neutropenia, anemia, neuropathy , insomnia, nasal symptoms and musculoskeletal pain.
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Adult and Children 12 years and over: One tablet twice daily (150mg lamivudine/300mg zidovudine per tablet). Not recommended in children under 12 y ears.
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The incidence and clinical significance of mitochondrial dysfunction after in utero exposure to AZT are therefore still unknown and require further study. If indicated, the drug should not be withheld because of pregnancy
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The Centers for Disease Control and Prevention (CDC) and other experts recommend that HIV-infected women not breast-feed infants, regardless of antiretroviral therapy due to the risk of transmitting the virus through breastfeeding.
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