Formulary Monographs [HYDROXYCHLOROQUINE, 083008]
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HYDROXYCHLOROQUINE
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ANTIMALARIALS
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Used in both the treatment and sup p ression of malaria, as well for the treatment of rheumatoid arthritis and sy stemic lup us ery thematosus.
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Adverse effects following short -term therap y include rash, vertigo,
transient headache and gastrointestinal comp laints such as nausea, vomiting, diarrhea and abdominal cramps. Ocular toxicity such as retinopathy , hair bleaching, alopecia, pruritus, changes in skin pigmentation and anaemia has been observed with long-term therap y or high dosages. |
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Lupus: Initially , 400mg 1-2 times daily until remission. Maintenance: 200-400mg daily . Take with food or milk.
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Healthcare professionals are reminded to consider the benefits and risks of co-prescribing systemic azithromycin, or other systemic macrolides, with hydroxychloroquine, if this cannot be avoided , patients should be monitored and told to seek medical attention if cardiac symptoms developed. Psychiatric reactions associated with hydroxychloroquine (including rare cases of suicidal behaviour) typically occurred within the first month of treatment; events have been reported in patients with no history of psychiatric disorders.
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It is not necessary to withdraw an antimalarial drug during pregnancy if the rheumatic disease is well controlled; however, the manufacturer of hydroxychloroquine advises avoiding use.
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It is advised to avoid due to the potential risk of toxicity in the infant. monitor infant for symptoms of uveitis e.g. eye redness or sensitivity to light.
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