Formulary Monographs [FLUCONAZOLE, 081408]
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FLUCONAZOLE
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AZOLES
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Treatment of orophary ngeal and esophageal candidiasis, systemic candidal infections, vaginal candidasis, urinary tract infections, pneumonia, and peritonitis. Also, acquired immunodeficiency syndrome patients with cryptococcal meningitis, as suppressiv
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Nausea, vomiting, diarrhoea, elevations in liver functions tests and alopecia. Low dose does not appear to increase risk of congenital abnormalities in t he first trimester.
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Oropharyngeal and esophageal candidiasis: 200mg on day 1 then
100mg PO/IV daily for at least 2 weeks. Systemic candidiasis: 400mg PO/IV once daily for 4 weeks and for at least 2 weeks orally after resolution of symptoms. Vaginal candidiasis: 150mg ora |
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Clindamycin, Calcium channel blockers, Phenothiazines and Tricyclic antidepressants - increased risk of cardiotoxicity. Simvastatin and Cerivastatin - increased risk of Rhabdomyolysis. Amlodipine - increases amlodipine toxicity .
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Avoid use in pregnancy. Multiple congenital abnormalities has been reported with long-term high doses.
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