Formulary Monographs [ESTRADIOL, 681604]
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ESTRADIOL
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CONJUGATED EQUINE ESTROGENS
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HRT (maybe cyclical and progestogen should be added for 10-14 days of the cycle or may be continuously combined). Prevention of post-menopausal osteoporosis and vascular disease. Atrophic vaginitis; atrophic urethritis, estrogen replacement.
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Less thromboembolic disease than semisyntheticor synthetic oestrogen, spotting, breast tenderness,chloasma, weight changes. c.f. prescribing in liver disease p. 16.
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Oral: 0.5-2mg daily. Vaginal: 2-4g (0.2-0.4mg oestradiol) daily for 1-2 weeks, then increase to 1-2g/day for 1-2 weeks; then maintainance dose of 1g 1-3 times weekly for 3 weeks, then off for 1 week; then repeat cycle once vaginal mucosa has been restored
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