Formulary Monographs [CYCLOSPORIN, 1000]
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CYCLOSPORIN
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ANTINEOPLASTICS
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Prophylaxis of graft rejection in Organ and tissue transplantation.
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Abdominal pain; anorexia; diarrhoea; fatigue; gingival hyperplasia; headache; hepatic dysfunction. Renal dysfunction (renal structural changes on long-term administration).
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Ciclosp orin is 10 to 15 mg/kg daily , beginning 4 to 12 hours before
transp lantation, and continued for 1 to 2 weeks. maintenance 2-6 mg/kg daily, reduce dose gradually to maintenance |
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Cyclosporin crosses the placenta; manufacturer advises to avoid unless potential benefit outweighs risk.
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Avoid breastfeeding during cyclosporin therapy.
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