Formulary Monographs [CYCLOPHOSPHAMIDE, 1000]
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CYCLOPHOSPHAMIDE
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ANTINEOPLASTICS
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Non-Hodgkin’s lymphomas.
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High fluid intake will help to prevent haemorrhagic cystitis (3-4 litres/day ). C.f. prescribing in renal disease p. 27.
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Low-dose: 2-6 mg/kg weekly as a single i.v. dose/ in divided oral doses; moderate-dose:10-15 mg/kg weekly as a single i.v. dose; High-dose: 20-40 mg/kg as a single i.v. dose every 10-20 days, depending on the disease being treated, condi
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Cyclophosphamide can cause fetal toxicity when administered to pregnant women, but potential benefits from use of the drug may be acceptable in certain conditions despite the possible risks to the fetus.
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Discontinue breast-feeding during and for 36 hours after stopping treatment.
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