Formulary Monographs [CHLOROQUINE PHOSPHATE, 083008]
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CHLOROQUINE PHOSPHATE
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ANTIMALARIALS
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Acute and prophylactic treatment of malaria. Active rheumatoid arthritis and Systemic and discoid lupus erythematosus
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For prophylaxis, drug should be taken on the same day each week. Nausea, vomiting, abdominal cramps, blurred vision. caution is recommended in patients with risk factors for cardiac events and they should be advised to seek urgent medical attention if any signs or symptoms develop. Ocular toxicity is unlikely if the dose of chloroquine phosphate does not exceed 4 mg/kg daily
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1g to start, 500mg in 6 hours and 500mg daily for 2 days. Prophylaxis: 500mg per week, 1 week before exposure and continuing throughout and for 4 week after exposure.
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Avoid taking an antacid or Kaopectate (kaolin-pectin) within 4 hours before or 4 hours after chloroquine.
Avoid alcohol. |
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Benefit of use in prophylaxis and treatment in malaria outweighs risk.
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Present in breast milk and breast-feeding should be avoided when used to treat rheumatic disease. Amount in milk probably too small to be harmful when used for malaria.
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