Formulary Monographs [CAPECITABINE, 1000]
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CAPECITABINE
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ANTINEOPLASTICS
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Metastatic colorectal cancer, locally advanced or metastatic breast cancer after failure of anthracycline-containing chemotherapy.
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Diarrhoea (which may be severe), nausea and vomiting, abdominal pain, stomatitis.
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Initial oral dose 1.25 g/m2 given twice daily . Doses are given for 14 days, followed by a 7-day rest period.
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Capecitabine may cause fetal harm when administered to pregnant women. Capecitabine should be used during pregnancy only in life-threatening situations or severe disease for which safer drugs cannot be used or are ineffective.
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Because of the potential for serious adverse reactions to capecitabine in nursing infants, nursing should be discontinued during capecitabine therapy.
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