Formulary Monographs [BUSULPHAN, 1000]
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BUSULPHAN
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ANTINEOPLASTICS
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Chronic myeloid leukaemia.
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Leukopenia, thrombocytopenia, anaemia, amenorrhoea, (occasional), skin hyperpigmentation (occasional), gynecomastia (occasional) Adisonian - like wasting syndrome, pulmonary fibrosis (rare). Maintain ample fluid intake.
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60 micrograms/kg daily , with a usual maximum single daily dose of
4 mg. Maintenance: 0.5-2mg daily . |
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Busulfan may cause fetal harm when administered to pregnant women, but potential benefits from use of the drug may be acceptable in certain conditions despite the possible risks to the fetus.
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Discontinue breast-feeding.
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