Formulary Monographs [ANTITUBERCULARS, 0816]
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ANTITUBERCULARS
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ANTIMYCOBACTERIALS
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The treatment of tuberclosis can be divided into
two phases, an initial phase where three drugs are used and a second or continuation phase where two drugs are used. The recommended regime is an initial phase of Isoniazid, Rifampicin and either Streptomycin or Etham-butol for two months and a continuation phase of Isoniazid and Rifampicin for seven months i.e. a total treatment time of nine months. Isoniazid is still con-sidered to be the primary drug for chemotherapy of tuberculosis. Cautions/Side Effects Patients on long term Isoniazid should be given Pyridoxine Hydrochloride prophylactically.Rifampicin is a potent inducer of liver enzymes and may provide important interactions with other drugs. (see p. 42) |