| Active Ingredient | AMITRIPTYLINE |
| Therapeutic Class | TRICYCLICS & OTHER NOREPINEPHRINE REUPTAKE INHIBIT |
| Indications | Agitated depression. |
| Caution | Acute retention especially in prostatic hypertrophy. Tricyclics may antagonise the action of adrenergic neurone blocking drugs e.g. guanethidine, and may seriously impair their antihypertensive effec More ... |
| Dose Range | 50-200mg daily in divided doses. |
| Drug Interactions | |
| Pregnancy | |
| Breast Feeding |
| Active Ingredient | CLOMIPRAMINE |
| Therapeutic Class | TRICYCLICS & OTHER NOREPINEPHRINE REUPTAKE INHIBIT |
| Indications | Most useful in obsessional and phobic disorders. |
| Caution | See amitriptyline hydrochloride. Weight gain, urinary retention, tremor. C.f. prescribing in liver disease. P. 12. |
| Dose Range |
Initially 25 mg daily (or 10 mg daily for elderly patients or those sensitive to tricyclics) increased gradually over two weeks to 100 to 150 mg daily . |
| Drug Interactions | |
| Pregnancy | |
| Breast Feeding |
| Active Ingredient | IMIPRAMINE |
| Therapeutic Class | TRICYCLICS & OTHER NOREPINEPHRINE REUPTAKE INHIBIT |
| Indications | Treatmment of juvenile enuresis. Depressive illness. |
| Caution | Causes less confusion in the elderly. c.f. prescribing in liver disease p.14. See amitripty line. |
| Dose Range |
Adult: Initially up to 75mg in divided doses, gradually increasing to 150-200mg. In the elderly initial dose of 10mg daily increased gradullay to 30-50mg daily. Paediatric: 6-7 yrs 25 mg 8-11 yrs 25- 50mg, 11-18yrs 50-75mg at bedtime innocturnal enuresis |
| Drug Interactions | |
| Pregnancy | |
| Breast Feeding |