| Active Ingredient | CHLORDIAZEPOXIDE |
| Therapeutic Class | PHENOTHIAZINES |
| Indications |
For short term relief of anxiety and tension in neuroses. Adjunct in acute alcohol withdrawal. Also see Major Tranquliser on p.265. |
| Caution | Dizziness, drowsiness, ataxia and slurred speech. Short term usage recommended because they are habit forming. Not recommended in children. C.f. prescribing in liver and renal disease p. 12; 25. |
| Dose Range | Anxiety: 10mg 3 times daily increased if necessary to 60-100mg daily in divided doses. Alcohol withdrawal Syndrome: 25-100 mg repeated as needed after 2 to 4 hours, up to a maximum of 300 mg daily . Elderly: half adult dose. |
| Drug Interactions | |
| Pregnancy | |
| Breast Feeding |
| Active Ingredient | CHLORPROMAZINE |
| Therapeutic Class | PHENOTHIAZINES |
| Indications | To control psychotic excitement. |
| Caution | Drowsiness, precipitating confusional psychoses and postural hypotension with injections, nasal congestion and dry mouth. C.f. prescribing in liver and renal disease p. 12; 26. |
| Dose Range |
Oral: 75-300mg daily in divided doses. (But up to 1g may be given in p sy choses). Inj: 25-50mg p er every 6-8 hours. |
| Drug Interactions | |
| Pregnancy | |
| Breast Feeding |
| Active Ingredient | FLUPHENAZINE |
| Therapeutic Class | PHENOTHIAZINES |
| Indications |
Schizophrenia and other psychoses. Depot injections for ambulant psychotics. |
| Caution | Parkinsonian extrapy ramidal effects, drowsiness, hypotension. |
| Dose Range | Adult: Tab: 2-10mg daily in divided doses. Inj: 12.5-100mg monthly. |
| Drug Interactions | |
| Pregnancy | |
| Breast Feeding |
| Active Ingredient | PERPHENAZINE |
| Therapeutic Class | PHENOTHIAZINES |
| Indications | Useful in paranoid states. [Schizop hrenia] |
| Caution | Less drowsiness and hypotension. Less blood dycrasias of jaundice. See chlorp romazine. C.f. prescribing in liver and renal disease p.16; 34. Not recommended in children under 14yrs. |
| Dose Range |
Adult: 12-24mg daily in divided doses. Elderly: Use quarter-half of adult dose. |
| Drug Interactions | |
| Pregnancy | |
| Breast Feeding |
| Active Ingredient | PROCHLORPERAZINE |
| Therapeutic Class | PHENOTHIAZINES |
| Indications | Minimum use in psychiatry . Antiemetic. |
| Caution | c.f. prescribing in liver and renal disease p.17;35. See chlorpromazine. |
| Dose Range |
Psychiatry: 25-100mg daily in divided doses. Anti-emetic: 5-10mg 2-3 times daily . |
| Drug Interactions | |
| Pregnancy | |
| Breast Feeding |
| Active Ingredient | THIORIDAZINE |
| Therapeutic Class | PHENOTHIAZINES |
| Indications | When heavy sedation is not required. For restless, confused geriatric patients at night. Schizophrenia and other psychoses |
| Caution | Causes less extrapy ramidal problems. Possibility of retinal pigmentation after prolonged usage and at doses over the maximum. More likely to induce hypotension. Contraindicated in cardiac disease. C More ... |
| Dose Range | Adult: 150-300mg in 3 divided doses to a maximum of 800mg/day . Elderly: 30-100mg daily . Pediatric: 0.5mg/kg/day in divided doses to a maximum of 3mg/kg/day . |
| Drug Interactions | |
| Pregnancy | |
| Breast Feeding |
| Active Ingredient | TRIFLUOPERAZINE |
| Therapeutic Class | PHENOTHIAZINES |
| Indications | Paranoid and withdrawn states. |
| Caution | Extrapy ramidal symptoms, ocular pigmentation. C.f. prescribing in liver and renal disease p. 18; 38. Safety and efficacy have not been established in children under 6yrs of age. |
| Dose Range |
Adult: 2- 5 mg twice daily, gradually increased to a usual range of 15-20 mg daily; in severe or resistant psychoses daily doses of 40 mg or more have been given. Pediatric under 12 yrs: Up to 5mg once daily . |
| Drug Interactions | |
| Pregnancy | |
| Breast Feeding |