| Active Ingredient | ALPRAZOLAM |
| Therapeutic Class | BENZODIAZEPINES (SEDATIVES) |
| Indications | Indicated for anxiety and panic disorders. |
| Caution | Adverse effects include dizziness, sleepiness, syncope, confusion, impaired memory and co-ordination, decreased libido, increased appetite, depression, and constipation. Withdrawal seizures may occur More ... |
| Dose Range | Anxiety: 0.25-0.5mg 3 times daily increased if necessary to a total daily dose of 3 or 4mg. Panic disorders: 0.5-10mg daily divided into 3-4 doses. Elderly: initially 0.25mg 2 or 3 times daily . |
| Drug Interactions | |
| Pregnancy | |
| Breast Feeding |
| Active Ingredient | CLOBAZAM |
| Therapeutic Class | BENZODIAZEPINES (SEDATIVES) |
| Indications | Adjunct in the treatment of epilepsy including seizures associated with the Lennox-Gastaut syndrome. Short-term treatment of acute anxiety. |
| Caution | As for diazepam. |
| Dose Range | Adult: Epilepy: 20 to 30 mg daily, maximum dose 60 mg daily . Acute anxiety: 10 to 30 mg daily may be taken in divided doses or as a single dose at night. Pediatric 6-17 years: initially 5 mg daily with a maintenance dose range of 0.3 to 1 mg/kg daily up |
| Drug Interactions | |
| Pregnancy | |
| Breast Feeding |
| Active Ingredient | DIAZEPAM |
| Therapeutic Class | BENZODIAZEPINES (SEDATIVES) |
| Indications | Short term use as tranquilliser, sedative, and in status epilepticus, acute alcohol withdrawal. Also see chlordiazepoxide. |
| Caution |
See chlordiazepoxide above. Excessive drowsiness and confusion in the elderly. Flumazenil as Anexate is available at the Q.E.H. for the treatment of benzodiazepine overdosage. C.f. prescribing in live More ... |
| Dose Range |
Anxiety: 2-30mg daily, usually best as a single night time dose. Status epilepticus: 10-20mg i.v. at 5mg/minute. Repeat cautiously if necessary. Acute alcohol withdrawal: 10mg 3-4 times a day for 1 day, then 5mg 3-4 times a day when necessary . |
| Drug Interactions | |
| Pregnancy | |
| Breast Feeding |
| Active Ingredient | LORAZEPAM |
| Therapeutic Class | BENZODIAZEPINES (SEDATIVES) |
| Indications |
Quick relief of anxiety symptoms but action not sustained. See p. 265. |
| Caution | See Chlordiazepoxide Hydrochloride p. 319. It is habit forming and on sudden withdrawal may cause seizures. c.f. prescribing in liver disease p.15. |
| Dose Range | Anxiety: 1-6mg daily in divided doses but may be gradually increased to 10mg daily in 2-3 divided doses. Elderly: Half adult dose. i.v 4mg given by slow intravenous injection. |
| Drug Interactions | |
| Pregnancy | |
| Breast Feeding |
| Active Ingredient | MIDAZOLAM |
| Therapeutic Class | BENZODIAZEPINES (SEDATIVES) |
| Indications | Sedation in minor surgical or investigative procedures and in intensive care, for premedication, and for induction of general anaesthesia. |
| Caution | Dosage must be titrated carefully against the response of the patient; lower doses of midazolam are required when it is used with op ioid analgesics. Respiratory and cardiac function should be monitor More ... |
| Dose Range | |
| Drug Interactions | |
| Pregnancy | |
| Breast Feeding |
| Active Ingredient | NITRAZEPAM |
| Therapeutic Class | BENZODIAZEPINES (SEDATIVES) |
| Indications | Short term use for insomnia. |
| Caution | Avoid prolonged ues. Use with cauion in heptic and renal impairment. Drowsiness, lightheadedness, disorientation, confusion. Effects may be more accentuated in elderly patients. c.f. prescribing in More ... |
| Dose Range | Adult: 5-10mg at bedtime. |
| Drug Interactions | |
| Pregnancy | |
| Breast Feeding |