| Active Ingredient | THYROXINE |
| Therapeutic Class | THYROID AGENTS |
| Indications | Hypothyroidism. |
| Caution | Angina, sweating, headache, diarrhoea, tachycardia (features of thyrotoxicosis), weight loss, restlessness. |
| Dose Range |
50-100mcgs daily increased by 25-50mcg at intervals of about 4 weeks. Maintenance Dose: 100-200mcgs daily. Best taken on an empty stomach Start at low dose (12.5-50mcg daily ) in elderly or patients with ischaemic heart disease. |
| Drug Interactions | |
| Pregnancy | |
| Breast Feeding |
| Active Ingredient | CARBIMAZOLE |
| Therapeutic Class | ANTI-THYROID AGENTS |
| Indications | Hyperthyroidism. |
| Caution | Monitor carefully in pregnancy and breast feeding as overdose may cause fetal and neonatal thyroid depression. May cause skin rashes, joint swelling, arthalgias. |
| Dose Range |
Adult: 15- 40 mg (up to 60 mg) daily in divided doses until patient is euthyroid. Maintenance dose 5 to 15 mg daily , as a single dose. Pediatric: 0.75 mg/kg (max.30 mg) daily as single or divided doses. 12-18 y rs: 30mg daily initially , in single or div |
| Drug Interactions | |
| Pregnancy | |
| Breast Feeding |
| Active Ingredient | PROPYLTHIOURACIL |
| Therapeutic Class | ANTI-THYROID AGENTS |
| Indications | Hyperthyroidism. |
| Caution | Fever, leukopenia, rash. |
| Dose Range |
Adult: 200-400 mg daily (600-1200 mg in severe cases) in single or divided doses until euthyroid. Maintenance dose: 50-150 mg daily . Paediatric: neonates: 2.5-5 mg/kg twice daily ; 1 month to 1 yr: 2.5 mg/kg 3 times daily : 1- 18y rs: 25 -100mg 3 tim |
| Drug Interactions | |
| Pregnancy | |
| Breast Feeding |