Displaying 1 - 1 of 1
| Active Ingredient | SPIRONOLACTONE |
| Therapeutic Class | ALDOSTERONE RECEPTOR ANTAGONIST |
| Indications | Oedema in Congestive Heart Failure (CHF).It is frequently given with the thiazides, furosemide, or similar diuretics, where it adds to their natriuretic but diminishes their kaliuretic effects, he More ... |
| Caution |
May cause hyperkalemia in renal failure; gynaecomastia, nausea, vomiting, drowiness. C.f. prescribing in renal disease p. 36. |
| Dose Range |
Adults and Children over 12yrs: Odema: 100-200mg daily in single or divided doses to a maximum of 400mg daily. Moderate to severe heart failure (Adjunct): initially 25mg increased to a maximum of 50mg once daily . Pediatric 1mth-12yrs: 1-3mg/kg in 1 or 2 |
| Drug Interactions | |
| Pregnancy | Safe use of spironolactone during pregnancy has not been established. The drug s More ... |
| Breast Feeding | Spironolactone enters breastmilk and is not recommended in lactating women. |