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| Active Ingredient | METHOTREXATE |
| Therapeutic Class | ANTINEOPLASTICS |
| Indications | Rheumatoid arthritis, acute lymphoblastic leukaemia. |
| Caution | Stomatitis, diarrhoea, hepatic dysfunction, thrombocy top enia, bone marrow suppression. Pulmonary toxicity in rheumatoid arthritis (patient to contact doctor immediately if dyspnoea or cough occ More ... |
| Dose Range | Rheumatoid Arthritis: 7.5mg once weekly or 2.5mg every 12 hours for 3 doses. Max. total weekly dose 20mg. Acute lymphoblastic leukaemia: Low-dose: individual doses under 100 mg/m2; moderate- dose: individual doses between 100 mg/m2 and 1g/M 2; |
| Drug Interactions | |
| Pregnancy | Methotrexate may cause fetal death and/or congenital abnormalities. |
| Breast Feeding | Methotrexate is distributed in breastmilk. Breastfeeding is not recommended duri More ... |