Formulary Monographs [GENTAMICIN, 081202]

Septicaemia and neonatal sepsis, biliary infections, intraabdominal and UTI, acute pyelonephritis. Severe gram-negative infections, primarily pseudomonas infections.
Increase dose interval in renal impairment in children and the elderly. Use nomogram (see renal disease guidelines p.19-38) and check peak (1 hour) and trough (predose) levels. Nehrotoxicity or ototoxicity may occur. C.f. prescribing in renal disease p. 30.
i.m. 3-5mg/kg/day in divided doses every 8 hours for 7-10 days. 12
hours (clearance 30-70 ml/min), 24 hours (clearance 10-30ml/min, 48 hours (clearance 5-10ml/min)
Risk of auditory or vestibular nerve damage in the infant when aminoglycosides are used in the second and third trimesters of pregnancy.The risk is probably very small with gentamicin.