Formulary Monographs [CHLORPHENIRAMINE, 0404]
|
|
CHLORPHENIRAMINE
|
|
|
|
|
|
FIRST GENERATION ANTIHISTAMINE
|
|
|
Hay fever, allergic rhinitis, urticaria (prevention and treatment) and pruritis associated with skin disorders; emergency treatment of anaphylactic reactions.
|
|
|
Dryness of mouth. Injections may be irritating and may cause transient hypotension. May cause drowsiness, if affected do not drive or operate machinery; avoid alcohol.
|
|
|
4-24mg in divided doses. Slow I.V . injection, SC or I.M: 10-
20mg, repeated if required. Maximum: 40mg in 24 hours. Pediatric: Not recommended under 1 year, 1-2 y ears 1mg twice daily , 2-6 years 1mg every 4-6 hours, maximum of 6mg daily , 6-12 years 2mg |
|
|
|
|
|
Use in the latter part of the third trimester may cause adverse effects in neonates such as irritability, paradoxical excitability, and tremor.
|
|
|
Most antihistamines are present in breast milk in varying amounts; although not known to be harmful, most manufacturers advise avoiding their use in mothers who are breast-feeding.
|
|
|
|