Formulary Monographs [CHLORPHENIRAMINE, 0404]

Hay fever, allergic rhinitis, urticaria (prevention and treatment) and pruritis associated with skin disorders; emergency treatment of anaphylactic reactions.
Dryness of mouth. Injections may be irritating and may cause transient hypotension. May cause drowsiness, if affected do not drive or operate machinery; avoid alcohol.
4-24mg in divided doses. Slow I.V . injection, SC or I.M: 10-
20mg, repeated if required. Maximum: 40mg in 24 hours. Pediatric:
Not recommended under 1 year, 1-2 y ears 1mg twice daily , 2-6 years 1mg every 4-6 hours, maximum of 6mg daily , 6-12 years 2mg
Use in the latter part of the third trimester may cause adverse effects in neonates such as irritability, paradoxical excitability, and tremor.
Most antihistamines are present in breast milk in varying amounts; although not known to be harmful, most manufacturers advise avoiding their use in mothers who are breast-feeding.