Formulary Monographs [CASPOFUNGIN, 081416]
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CASPOFUNGIN
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ECHINOCANDINS
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Invasive aspergillosis in patients refractory to, or intolerant of, other therapy. Invasive candidiasis; empirical therapy for presumed fungal infections in febrile, neutropenic patients.
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Diarrhoea, nausea, vomiting, flushing, headache, fever, tachycardia, venous complications around the infusion site. Possible histamine- mediated symptoms have included rash, facial swelling, pruritus, sensation of warmth, or bronchospasm. Hypokalaemia and decreased red and white blood cell counts are common.
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Adult: 70mg as a loading dose on the first day, followed by 50mg daily given as a slow IV infusion over 1 hour. Children: 70 mg/m2 loading dose on the first day, followed by 50 mg/m2 once daily thereafter given by intravenous infusion over about 1 hou
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Use is not advised unless necessary.
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