Displaying 81 - 100 of 853
Active Ingredient ETHAMBUTOL
Therapeutic Class ANTITUBERCULOSIS AGENTS
Indications Tuberculosis, in combination with other drugs.
Caution Optic neuritis. Use with caution in renal disease, and in the elderly . Avoid in children under 6 years. Visual acuity and red-green colour discrimination occurs at doses of 25mg/kg. May cause G.I. u More ...
Dose Range Adult: 15 mg/kg/day as a single dose, alternatively, three times weekly (25 to 30 mg/kg/dose) or twice weekly (50 mg/kg/dose) dosing has been given; patients with renal insufficiency require dosage adjustment. Pediatric: 15-20mg/kg/day.Take with food.
Drug Interactions
Pregnancy The manufacturer states that ethambutol should be used during pregnancy only whe More ...
Breast Feeding
Active Ingredient ISONIAZID
Therapeutic Class ANTITUBERCULOSIS AGENTS
Indications Tuberculosis, in combination with other drugs
Caution Peripheral neuritis (treat with 50-100mg pyridoxine daily). Hepatitis (like viral hepatitis) convulsions, optic neuritis with atrophy . Monitor SGOT, SGPT, (if symptomatic) Albumin phosphatase. Avoid More ...
Dose Range Adult: 300mg (5mg/kg/day ) daily in a single dose. May also be given as 900mg (15mg/kg) twice weekly as a single dose. Pediatric:
10mg/kg daily. Take on empty stomach. May be taken with food to
avoid upset stomach.
Drug Interactions
Pregnancy Category: C Use with caution if benefits outweigh risks. Animal studies show ris More ...
Breast Feeding Distributed into milk but safe for nursing infants
Active Ingredient PYRAZINAMIDE
Therapeutic Class ANTITUBERCULOSIS AGENTS
Indications Tuberculosis as a second line drug in combination with other drugs.
Caution Hyperuricemia, acute gout, hepatotoxicity, G.I. upset. Diabetes mellitus becomes more difficult to manage. Monitor SGOT, SGPT and uric acid levels. Give intermittently to avoid hypercalcaemia.
Dose Range 15-30 mg/kg/day up to a max.of 2 g daily ; or 50-70 mg/kg 2-3 times weekly. Tuberculosis in AIDS p atients, doses of 20 to 30mg/kg/day have been successful. Dosage reduction is recommended in patients with endstage renal disease. Take with food to avoid
Drug Interactions
Pregnancy
Breast Feeding Because pyrazinamide is distributed into milk in small amounts, a decision shoul More ...
Active Ingredient RIFAMPICIN
Therapeutic Class ANTITUBERCULOSIS AGENTS
Indications Tuberculosis, in combination with other drugs.
Caution Orange coloured urine, tears and saliva. Flu-like syndrome, hepatitis, thrombocytopenia, hemolysis, renal failure. Monitor SGOT, SGPT levels and discontinue if levels are more than twice normal. More ...
Dose Range Adult: 600mg/day . Pediatric: 10-20mg/kg/day, up to a maximum of
600 mg/day. The duration of therapy varies with the infection or condition being treated. Dosage adjustments should be considered in patients with liver disease. Take at least 30 minutes
Drug Interactions
Pregnancy
Breast Feeding
Active Ingredient CLOFAZIMINE
Therapeutic Class ANTIMYCOBACTERIALS, MISCELLANEOUS
Indications Leprosy.Indicated for treatment of lepromatous leprosy, including dapsone-resistant leprosy complicated by erythema nodosum leprosum
Caution Preferably used in combination with 1 or more other antileprosy agents to prevent the emergence of drug resistance.

Skin discoloration may occur. Gastrointestinal: Abdominal and epigastric pain, dia More ...
Dose Range Dapsone-resistant leprosy
100mg daily with food.combination with 1 or more other antileprosy drugs for 3 years, followed by monotherapy with 100 mg of clofazimine daily.

Dapsone-sensitive multibacillary leprosy

50 mg PO qDay in combination with dapsone
Drug Interactions
Pregnancy Use with caution.
Breast Feeding May alter colour of breastmilk and cause skin discoloration in neonates.
Active Ingredient DAPSONE
Therapeutic Class ANTIMYCOBACTERIALS, MISCELLANEOUS
Indications For the treatment of Leprosy.
Caution Hemolytic anemia, methemo-globinemia, aplastic anemia, psychoticn episodes, hepatotoxicity , nephrotic syndrome. May cause dizziness. Exercise caution when driving or operating machinery .
Dapsone More ...
Dose Range 100mg once daily.
Drug Interactions
Pregnancy Folic acid (higher dose) should be given to mother throughout pregnancy; neonata More ...
Breast Feeding Dapsone is distributed into breast milk but in small amounts. A decision should More ...
Active Ingredient ANTIVIRALS
Therapeutic Class ANTIVIRALS
Indications
Caution
Dose Range
Drug Interactions
Pregnancy
Breast Feeding
Active Ingredient AMANTADINE
Therapeutic Class ADAMANTANES
Indications
Caution
Dose Range
Drug Interactions
Pregnancy
Breast Feeding
Active Ingredient ANTIRETROVIRALS
Therapeutic Class ANTIRETROVIRALS
Indications
Caution
Dose Range
Drug Interactions
Pregnancy
Breast Feeding
Active Ingredient ATAZANAVIR
Therapeutic Class HIV PROTEASE INHIBITORS
Indications HIV-1 infection in treatment -naïve and treatment-experienced adults and pediatric patients 6 years of age or older.
Caution Rash, abdominal pain, diarrhoea, nausea, unconjugated hyper- bilirubinemia, headache, lactic acidosis.
Dose Range Adult: Atazanavir 300mg/ ritonavir 100mg once daily with food.
Drug Interactions
Pregnancy Theoretical risk of hyperbilirubinaemia in neonate if used at term.
Breast Feeding The Centers for Disease Control and Prevention (CDC) and other experts recommend More ...
Active Ingredient DARUNAVIR
Therapeutic Class HIV PROTEASE INHIBITORS
Indications
Caution
Dose Range
Drug Interactions
Pregnancy
Breast Feeding
Active Ingredient RITONAVIR
Therapeutic Class HIV PROTEASE INHIBITORS
Indications Not typically used as sole protease inhibitor (PI), but as pharmacokinetic enhancer of other PIs

Indicated in combination with other antiretroviral agents for the treatment of HIV-infection
See lopin More ...
Caution See lopinavir/ritonavir.Increased triglycerides, Diarrhea, Nausea , taste perversion,
Dose Range Initial dose 300mg twice daily gradually increased by 100mg twice
daily over a period of up to 14 days to a maximum of 600mg twice daily .
Drug Interactions
Pregnancy See lopinavir/ritonavir.
Breast Feeding The Centers for Disease Control and Prevention (CDC) and other experts recommend More ...
Active Ingredient SAQUINAVIR
Therapeutic Class HIV PROTEASE INHIBITORS
Indications Treatment of HIV infection in combination with ritonavir and other antiretroviral agents.
Caution Diarrhea, abdominal discomfort.
Dose Range Adults and children (16 yrs of age and older): 1g twice daily with ritonavir 100mg twice daily , or with lop inavir 400mg/ritonavir 100mg twice daily . Administer within 2 hours after a meal.
Drug Interactions
Pregnancy
Breast Feeding The Centers for Disease Control and Prevention (CDC) and other experts recommend More ...
Active Ingredient DOLUTEGRAVIR
Therapeutic Class INTEGRASE INHIBITORS
Indications
Caution
Dose Range
Drug Interactions
Pregnancy
Breast Feeding
Active Ingredient ELVITEGRAVIR
Therapeutic Class INTEGRASE INHIBITORS
Indications The fixed combination of elvitegravir, cobicistat, emtricitabine, and tenofovir disoproxil fumarate (tenofovir DF) (EVG/c/FTC/TDF) is used for the treatment of human immunodeficiency virus type 1 (HIV More ...
Caution Lactic acidosis and hepatomegaly with steatosis, including fatalities, have been reported with Tenofovir DF in combination with other antiretrovirals; risk is increased in women, obese patients, prolo More ...
Dose Range Elvitegravir is often given with a protease inhibitor, a pharmacokinetic enhancer such as low-dose ritonavir, and at least one other antiretroviral drug; the dose may need to be adjusted to manage drug interactions.
Drug Interactions Drugs that induce these enzymes may decrease its plasma concentration and it should not be used with strong inducers of CYP3A which include the following:
antibacterials (rifampicin)
antidepressants More ...
Pregnancy There are no or limited amount of data (less than 300 pregnancy outcomes) from t More ...
Breast Feeding In order to avoid transmission of HIV to the infant it is recommended that HIV i More ...
Active Ingredient RALTEGRAVIR
Therapeutic Class INTEGRASE INHIBITORS
Indications
Caution
Dose Range
Drug Interactions
Pregnancy
Breast Feeding
Active Ingredient EFAVIRENZ
Therapeutic Class NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIB (NNRTI)
Indications In combination with other antiretrovirals for the treatment of HIV-1
infection. Efavirenz usually is used in HIV nonnucleoside reverse transcriptase inhibitor-based (NNRTI-based) regimens that includ More ...
Caution Psychiatric disorders, rash, increases in liver enzymes.
Dose Range Adult: 600mg once daily on an empty stomach preferably at bedtime.
Pediatric: 3 years and older and weighing between 10-40kg:
200mg-600mg once daily .
Drug Interactions Efavirenz induces CYP3A and 2B6, and may alter plasma concentrations of drugs metabolized by these enzymes.
Pregnancy Efavirenz may cause fetal harm if administered during the first trimester of pre More ...
Breast Feeding The Centers for Disease Control and Prevention (CDC) and other experts recommend More ...
Active Ingredient NEVIRAPINE
Therapeutic Class NNRTI
Indications For use in combination with other antiretroviral agents for the treatment of HIV-1 infection. Nevirap ine reduces maternal to fetal HIV transmission.
Caution Nevirapine is generally well-tolerated. The primary adverse effects are fever, nausea, and headache. However severe and life-threatening skin reactions, toxic epidermal necroly sis and Stevens-Johnson More ...
Dose Range Adult: 200mg once daily for 14 day s, then increased to 200mg twice daily , in ombination with a nucleoside analogue antiretroviral agent. Pediatric: 2 months to 8 y ears: 4mg/kg/day for the first 14 day s followed by 7mg/kg twice daily . 8 y ea
Drug Interactions
Pregnancy The human pregnancy data for nevirapine suggest that the risk for embryo–fetal h More ...
Breast Feeding The Centers for Disease Control and Prevention (CDC) and other experts recommend More ...
Active Ingredient ABACAVIR
Therapeutic Class NRTI
Indications Indicated in combination with other anti-HIV medications for the
treatment of HIV-1 for adults and children.
Caution Nausea, vomiting, fatigue, headache, diarrhoea and loss of appetite. Fatal lactic acidosis and severe hep atomegaly with steatosis have been reported. Fatal hypersensitivity reactions include s More ...
Dose Range Adult: Recommended dosing is 300mg orally twice daily with or without food. Pediatric: 3 months - 16 years of age is 8mg/kg orally twice daily (up to a maximum of 300mg twice daily ). Abacavir should be used in combination with other antiretrovirals.
Drug Interactions Alcohol reduces the metabolism of abacavir.
Pregnancy The animal data suggest moderate risk. Although the human pregnancy experience d More ...
Breast Feeding The Centers for Disease Control and Prevention (CDC) and other experts recommend More ...
Active Ingredient DIDANOSINE
Therapeutic Class NRTI
Indications A first-line component of a combination antiretroviral therapy regimenfor HIV-1 infected p atients.
Caution Diarrhoea, neuropathy , chills or fever, rash, abdominal pain,weakness, headache and nausea/vomiting. Serious toxicities have included pancreatitis and lactic acidosis (which may be fata More ...
Dose Range Adult: weighing greater than 60kg, 200mg twice daily . Weighing less than or equal to 60kg, 125mg twice daily . Pediatric 8 months and older: 120mg/square meter twice daily . 2 weeks - 8 months: 100mg/square meter twice daily . Take on an empty stomach.
Drug Interactions Coadministration of Didanosine and allopurinol is contraindicated because systemic exposures of Didanosine are increased, which may increase Didanosine-associated toxicity
Pregnancy Reproduction studies have been performed in rats and rabbits at doses up to 12 a More ...
Breast Feeding The Centers for Disease Control and Prevention (CDC) and other experts recommend More ...