Active Ingredient | CLINDAMYCIN PHOSPHATE |
Therapeutic Class | LINCOMYCINS |
Indications | Staphylococcal bone or joint sepsis, peritonitis (alternative to gentamicin and metronidazole). Effective against many anaerobes. Bacteroides fragilis. Gram-positive cocci including penicillin-resista More ... |
Caution | Diarrhoea, pseudomembranous colitis. This is the commonest antibiotic causing it (responds to oral metronidazole or vancomycin). Report any excess diarrhoea, do not take anti-diarrhoeal drugs. |
Dose Range | Adult: 150-450mg every 6 hours. Pediatricunder12 years: 3-6 mg/kg/day every 6 hours. |
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Breast Feeding |
Active Ingredient | ANTIFUNGALS |
Therapeutic Class | ANTIFUNGALS |
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Breast Feeding |
Active Ingredient | TERBINAFINE |
Therapeutic Class | ALLYAMINES |
Indications | Onychomycosis.Indicated for onychomycosis of the toenail or fingernail owing to dermatophytes (tinea unguium |
Caution |
Headache, rash , nausea, diarrhea, dyspepsia, taste disturbance, elevated liver function test results, rarely, cases of liver failure, some leading to death or liver transplant. Skin and subcutaneo More ... |
Dose Range | 250mg once daily for 6-12 weeks. |
Drug Interactions | |
Pregnancy | Manufacturer advises use only if potential benefit outweighs risk. |
Breast Feeding | Accumulation in breastmilk prohibits use. |
Active Ingredient | CLOTRIMAZOLE |
Therapeutic Class | AZOLES |
Indications | Vaginal and vulval candidiasis. |
Caution | Local irritation and contact dermatitis may occur. |
Dose Range | Insert one applicatorful nightly of 1% cream for 7-14 nights, 2% cream for 3 nights, 10% cream stat dose or 200mg ovules into the vagina for 3 consecutive nights or 100mg ovule for 6 nights. Continue use during menstrual period. |
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Pregnancy | Pregnant women need a longer duration of treatment, usually about 7 days, to cle More ... |
Breast Feeding |
Active Ingredient | ECONAZOLE |
Therapeutic Class | AZOLES |
Indications | Yeast infections, candidiasis. |
Caution | Burning, stinging and erythema. |
Dose Range | 150mg once daily at bedtime for 3 consecutive nights. Continue use during menstrual period. |
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Pregnancy | Pregnant women need a longer duration of treatment, usually about 7 days, to cle More ... |
Breast Feeding |
Active Ingredient | FLUCONAZOLE |
Therapeutic Class | AZOLES |
Indications | Treatment of orophary ngeal and esophageal candidiasis, systemic candidal infections, vaginal candidasis, urinary tract infections, pneumonia, and peritonitis. Also, acquired immunodeficiency syndrome More ... |
Caution | Nausea, vomiting, diarrhoea, elevations in liver functions tests and alopecia. Low dose does not appear to increase risk of congenital abnormalities in t he first trimester. |
Dose Range |
Oropharyngeal and esophageal candidiasis: 200mg on day 1 then 100mg PO/IV daily for at least 2 weeks. Systemic candidiasis: 400mg PO/IV once daily for 4 weeks and for at least 2 weeks orally after resolution of symptoms. Vaginal candidiasis: 150mg ora |
Drug Interactions | Clindamycin, Calcium channel blockers, Phenothiazines and Tricyclic antidepressants - increased risk of cardiotoxicity. Simvastatin and Cerivastatin - increased risk of Rhabdomyolysis. Amlodipi More ... |
Pregnancy | Avoid use in pregnancy. Multiple congenital abnormalities has been reported with More ... |
Breast Feeding |
Active Ingredient | ISOCONAZOLE |
Therapeutic Class | AZOLES |
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Breast Feeding |
Active Ingredient | ITRACONAZOLE |
Therapeutic Class | AZOLES |
Indications | Treatment of vulvovaginal candidiasis, dermatophytoses unresponsive to topical treatment, systemic infections. |
Caution |
Abdominal pain; diarrhoea, dysnoea; headache; hepatitis; hypokalaemia; nausea; rash; taste disturbances; vomiting. Itraconazole should be avoided in patients with ventricular dysfunction or a history More ... |
Dose Range | Adult: Vulvovaginal candidiasis: 200mg twice daily for 1 day , Recurrent Vulvovaginal candidiasis: 50-100mg daily for 6 months. Systemic candidiasis: 100-200mg once daily . |
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Pregnancy | Manufacturer advises use only in lifethreatening situations (toxicity at high do More ... |
Breast Feeding | Small amounts present in milk—may accumulate; manufacturer advises avoid. |
Active Ingredient | ITRACONAZOLE | SECNIDAZOLE |
Therapeutic Class | AZOLES |
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Breast Feeding |
Active Ingredient | KETOCONAZOLE |
Therapeutic Class | AZOLES |
Indications | Vaginal candidiasis; prophylaxis of mycoses in immunosuppessed patients; systemic mycoses. To be used only in those patients who are resistant to fluconazole or terbinafine. |
Caution | Local irritation. Use with caution in patients with impaired hepatic function or adrenal reserve; blood dyscrasias, headache, dizziness, nausea, skin rash. The oral form may be taken with food or milk More ... |
Dose Range | Vaginal candidiasis: One ovule into the vagina at bedtime for 3 consecutive nights. |
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Breast Feeding |
Active Ingredient | MICONAZOLE |
Therapeutic Class | AZOLES |
Indications | Vaginal candidiasis |
Caution | Vaginal burning, irritation, contact dermatitis. |
Dose Range | One applicator full at night for 7 nights or 1 ovule at night for 3 nights. |
Drug Interactions | |
Pregnancy |
Pregnant women need a longer duration of treatment, usually about 7 days, to cle More ... |
Breast Feeding |
Active Ingredient | VORICONAZOLE |
Therapeutic Class | AZOLES |
Indications | Invasive aspergillosis in immunocompromised patients; candidaemia, in non-neutropenic patients, fluconazole-resistant serious invasive candidiasis, oesophageal candidiasis, and serious fungal infecti More ... |
Caution | Visual disturbances, fever, rashes, nausea, vomiting, diarrhoea, abdominal pain, headache, sepsis, respiratory disorders, and peripheral oedema. |
Dose Range |
IV: adults and adolescents: 6 mg/kg every 12 hours for the first 24 hours followed by maintenance dose of 4 mg/kg twice daily ; a lower dose of 3 mg/kg twice daily may be suitable for candidaemia in non- neutropenic patients or for deep tissue C |
Drug Interactions | |
Pregnancy | Because voriconazole can cause fetal harm, it should not be used during pregnanc More ... |
Breast Feeding | It is not known whether voriconazole is distributed into milk. |
Active Ingredient | CASPOFUNGIN |
Therapeutic Class | ECHINOCANDINS |
Indications | Invasive aspergillosis in patients refractory to, or intolerant of, other therapy. Invasive candidiasis; empirical therapy for presumed fungal infections in febrile, neutropenic patients. |
Caution | Diarrhoea, nausea, vomiting, flushing, headache, fever, tachycardia, venous complications around the infusion site. Possible histamine- mediated symptoms have included rash, facial swelling, pruritu More ... |
Dose Range | Adult: 70mg as a loading dose on the first day, followed by 50mg daily given as a slow IV infusion over 1 hour. Children: 70 mg/m2 loading dose on the first day, followed by 50 mg/m2 once daily thereafter given by intravenous infusion over about 1 hou |
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Pregnancy | Use is not advised unless necessary. |
Breast Feeding |
Active Ingredient | AMPHOTERICIN B |
Therapeutic Class | POLYENES |
Indications | Reserve for life threatening systemic fungal infections. |
Caution | Anemia, thrombocytopenia, CHF, anaphylaxis, fever, gastro-intestinal upset, nephrotoxicity (reduce with i.v. infusion of mannitol), tinnitus. Monitor Kidney Function. C.f. prescribing in renal disease More ... |
Dose Range |
Adult and Children: i.v. 0.25mg/kg/day as a single dose, with increments every other day to a maximum of 1.5 mg/kg/day . |
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Pregnancy | Not known to be harmful but manufacturers advise avoid unless potential benefit More ... |
Breast Feeding |
Active Ingredient | NYSTATIN |
Therapeutic Class | POLYENES |
Indications | For yeast infections; treatment of oral and vaginal candidiasis, and prophylaxis of intestinal candidiasis. |
Caution | Nausea, vomiting, diarrhoea (tablets), vaginal irritation |
Dose Range |
Adult: 4-6mls 4 times daily. Pediatric: 100,000 units 3-4 times daily after feeds or food and continued for 48 hours after lesions have healed. Retain suspension around in mouth for as long as possible, then swallow. |
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Breast Feeding |
Active Ingredient | ANIDULAFUNGIN |
Therapeutic Class | ANTIFUNGALS, MISCELLANEOUS |
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Breast Feeding |
Active Ingredient | CICLOPIROX OLAMINE |
Therapeutic Class | ANTIFUNGALS, MISCELLANEOUS |
Indications | Treatment of fungal infections, especially candidiasis. |
Caution | Burning or pruritus. |
Dose Range | Insert one applicatorful into the vagina at night, for 6 consecutive nights. |
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Pregnancy | |
Breast Feeding |
Active Ingredient | GRISEOFULVIN |
Therapeutic Class | ANTIFUNGALS, MISCELLANEOUS |
Indications | Severe tinea infections. Not effective against candida albicans. |
Caution | Headache, gastrointestinal upset, rash, dry mouth, photosensitivity. Affects warfarin metabolism. Avoid in pregnancy, liver failure. |
Dose Range | Adult: 500mg-1g daily as a single dose or in divided doses (1g is for difficult to treat fungal infections) after meals for 30 days or more. Pediatric: 5-10mg/kg daily in 2 divided doses or as a single dose after meals. The oral suspension is reserved f |
Drug Interactions | |
Pregnancy | Griseofulvin studies have shown the drug to be embryotoxic and/or teratogenic in More ... |
Breast Feeding | Avoid use unless potential benefit outweighs risk. |
Active Ingredient | METRONIDAZOLE | MICONAZOLE |
Therapeutic Class | ANTIFUNGALS, MISCELLANEOUS |
Indications | Bacterial Vaginosis, Trichomonal Vaginitis, Vaginal Candidiasis . |
Caution | Vaginal burning, irritation. Not to be used during pregnancy particularly the first 3 months. Avoid alcohol during and for at least 24-48 hours after treatment. |
Dose Range | One applicatorful or one ovule at bedtime for 7 nights. |
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Pregnancy | |
Breast Feeding |
Active Ingredient | ANTITUBERCULARS |
Therapeutic Class | ANTIMYCOBACTERIALS |
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