Active Ingredient | AMOXICILLIN |
Therapeutic Class | PENICILLINS |
Indications | Amoxicillin shares the uses of other aminopenicillins and is used principally for the treatment of infections caused by susceptible gram-negative bacteria (e.g., Haemophilus influenzae, Escherichia co More ... |
Caution | Rashes, especially in infectious mono-nucleosis. Shake susp. well before taking dose. Liquid may be mixed with formula, milk, fruit juice, water or ginger ale and taken immediately. Must be taken for More ... |
Dose Range | Adult: 250mg - 500mg 3 times daily. Pediatric: 1mth-1 yr: 62.5mg-125mg every 8 hours; 1yr-5 yrs: 125mg every 8 hours; from 5 yrs; 250mgevery 8 hours. |
Drug Interactions | |
Pregnancy | Not known to be harmful. |
Breast Feeding | Trace amount in milk, but appropriate to use. |
Active Ingredient | AMOXICILLIN | CLAVULANIC ACID |
Therapeutic Class | PENICILLINS |
Indications | Infections due to beta-lactamase-producing strains where amoxicillin alone is not appropriate. |
Caution | Hepatitis; nausea; vomiting, risk of cholestatic jaundice, hence treatment should not usually exceed 14 days. |
Dose Range | Calculated on amoxicillin content, similar to those for amoxicillin used alone. |
Drug Interactions | |
Pregnancy | |
Breast Feeding | Because amoxicillin and clavulanic acid are distributed into milk, amoxicillin a More ... |
Active Ingredient | AMPICILLIN |
Therapeutic Class | PENICILLINS |
Indications | For infections caused by H. influenzae and Strep. moniae and any other susceptible organisms. However, please note that the oral forms have been replaced by amoxicillin. |
Caution |
Erythema multiforme, Exfoliative dermatitis, rash , urticaria , fever , seizure, diarrhea, black hairy tongue, nausea, oral candidiasis, vomiting, Use caution in allergy to cephalosporins, carbapenem More ... |
Dose Range | Adult: 500mg-1g every 4-6 hours. Pediatric: 25-50mg/kg/day in divided doses every 4-12 hours; maximum 2g every 4 hours. |
Drug Interactions | |
Pregnancy | Pregnancy category: B. B: May be acceptable. Either animal studies show no risk More ... |
Breast Feeding | Trace amounts in milk, but appropriate to use. |
Active Ingredient | CLOXACILLIN |
Therapeutic Class | PENICILLINS |
Indications | Infections caused by penicillin resistant staphylocci. |
Caution | As for penicillin G. Oral absorption is complete. Take on empty stomach. |
Dose Range |
Adult: 500mg every 6 hours. Pediatric 1 mth and over: 50- 100mg/kg/day every 6 hours;orally. See BDS supply protocols pg. 3. |
Drug Interactions | |
Pregnancy | |
Breast Feeding |
Active Ingredient | PENICILLIN G BENZATHINE |
Therapeutic Class | PENICILLINS |
Indications | Streptococcal infections, diphtheria (asymptomatic carriers), pharyngitis, syphilis, primary and secondary prophylaxis of rheumaticfever. |
Caution | History of allergy, hypersensitivity. Urticaria, joint pains, fever, angioneurotic odema. Anaphylactic shock, hemolytic anemia, exfoliative dermatitis. |
Dose Range | 300,000-1.2 million units/day divided every 3-4 hours. |
Drug Interactions | |
Pregnancy | |
Breast Feeding |
Active Ingredient | PENICILLIN G SODIUM |
Therapeutic Class | PENICILLINS |
Indications | Tonsillitis, otitis media, erysipelas, streptococcal endocarditis, meningococcal and pneumococcal meningitis. Prophylaxis in limb amputation. |
Caution |
History of allergy and hypersensitivity. Urticaria, joint pains, fever, angioneurotic oedema, anaphylactic shock, diarrhoea. Renal impairment. C.f. prescribing in renal disease p. 23. |
Dose Range |
i.m or slow i.v: 0.6 to 4.8g daily in 4-6 divided doses.Severe infections e.g endocarditis, 7.2g daily (1.2g every 4hours) intravenously, usually with an aminogly coside. Meningococcal and pneumococcal meningitis, 14.4g daily (2.4g every 4 hours) intraven |
Drug Interactions | |
Pregnancy | |
Breast Feeding |
Active Ingredient | PENICILLIN V |
Therapeutic Class | PENICILLINS |
Indications | For the treatment of Streptococcal Pharyngitis,Periodontal Infections, Recurrent Rheumatic Fever, |
Caution |
.Diarrhea, Nausea,Oral candidiasis, vomiting , seizure , anemia, Positive Coombs reaction. May decrease the effectiveness of birth control pill. |
Dose Range | Adult and children 12 years and over: 250-500mg every 6 hours. Up to 1g in severe infections. Pediatric: 1 month-1 year: 62.5mg every 6 hours. 1-5 years: 125mg every 6 hours. 6-12 years 250mg every 6 hours. See BDS supply protocols pg. 3. |
Drug Interactions | |
Pregnancy | |
Breast Feeding |
Active Ingredient | PIPERACILLIN | TAZOBACTAM |
Therapeutic Class | PENICILLINS |
Indications | Moderate to severe infections caused by lactamase producing isolates of Staphylococcus aureus, isolates of H influenzae and isolates of E coli bacteria. |
Caution | Nausea, vomiting. Constipation, headache , fever, oral candidiasis, rash, pruritis, dyspepsia, hypertension |
Dose Range | 4.5g every 8 hours or 3.375g every 6 hours |
Drug Interactions | |
Pregnancy | |
Breast Feeding | Trace amount in milk, but appropriate to use. |
Active Ingredient | CIPROFLOXACIN |
Therapeutic Class | QUINOLONES |
Indications |
Ciprofloxacin is effective in a variety of infections due to gram- positive and gram-negative pathogens, including multi-resistant strains. It is also indicated for us in individuals exposed to inha More ... |
Caution | Gastrointestinal disturbances; CNS side effects, including seizures. Increases in transaminases and in some cases severe and fatal hepatitis have developed. Hematuria and anaphylactic reactions have More ... |
Dose Range | Adult: 250-750mg twice daily, depending on the severity of the infection. Inhalational post-exposure anthrax: 500mg every 12 hours. Pediatric: inhalational p ost-exposure anthrax: 10mg/kg every 12 hours. Maximum 400mg daily. See BDS supply protocols |
Drug Interactions | |
Pregnancy | Avoid in pregnancy—shown to cause arthropathy in animal studies; safer alternati More ... |
Breast Feeding | Amount too small to be harmful but manufacturer advises avoid. |
Active Ingredient | LEVOFLOXACIN |
Therapeutic Class | QUINOLONES |
Indications | Community -acquired pneumonia, urinary -tract infections, chronic prostatitis, complicated skin and soft tissue infections. |
Caution | Constipation; flatulence (in adults); hyperhidrosis (in adults). The drug should be discontinued if psychiatric, neurological, or hypersensitivity reactions (including severe rash) occur. |
Dose Range | Adult: 250 to 500 mg once or twice daily for 7 to 14 days depending on the severity and nature of the infection. Chronic prostatitis: 500mg once daily for 28 days. |
Drug Interactions | |
Pregnancy | Avoid in pregnancy—shown to cause arthropathy in animal studies; safer alternati More ... |
Breast Feeding | Manufacturer advises use only if potential benefit outweighs risk. |
Active Ingredient | MOXIFLOXACIN |
Therapeutic Class | QUINOLONES |
Indications | Bacterial conjunctivitis. |
Caution | Taste disturbances, ocular discomfort, irritation and dryness, hyperaemia, photophobia, visual disturbances and nasal discomfort. |
Dose Range |
Adult and child over 1 month: 3 times daily, continue treatment for 2-3 days after infection improves. |
Drug Interactions | |
Pregnancy | Avoid in pregnancy—shown to cause arthropathy in animal studies; safer alternati More ... |
Breast Feeding |
Active Ingredient | NORFLOXACIN |
Therapeutic Class | QUINOLONES |
Indications | Urinary tract infections, uncomp licated gonorrhea, and p rostatitis. |
Caution | Headache, depression, dizziness, nausea, vomiting, vaginal irritation and finger joint swelling. Take on an emp ty stomach with a large glass of water, drink several glasses of water during treatm More ... |
Dose Range |
Uncomplicated UTI: 400mg twice daily for 3-10 days; Complicated UTI: 400mg twice daily for 10-21 days. Uncomplicated gonorrhea: 800mg as a single dose. Acute or Chronic Prostatitis: 400mg twice daily for 28 days. See BDS supply protocols pg. 3. |
Drug Interactions | |
Pregnancy | Avoid in pregnancy—shown to cause arthropathy in animal studies; safer alternati More ... |
Breast Feeding |
Active Ingredient | OFLOXACIN |
Therapeutic Class | QUINOLONES |
Indications | Uncomplicated gonorrhea, nongonococcal urethritis, acute pelvic inflammatory disease, acute uncomplicated cystitis, complicated urinary tract infections,chronic bacterial prostatitis. |
Caution | Nausea, insomnia, headache, dizziness, diarrhea, vomiting, rash, and pruritus. The safety and efficacy of ofloxacin in pediatric patients and adolescents (under age 18 years), and pregnant and lactati More ... |
Dose Range | 200mg-400mg twice daily. A single oral dose of 400mg is indicated for uncomplicated gonorrhea. See BDS supply protocols pg. 3. |
Drug Interactions | |
Pregnancy | Avoid in pregnancy—shown to cause arthropathy in animal studies; safer alternati More ... |
Breast Feeding | Amount probably too small to be harmful but manufacturer advises avoid |
Active Ingredient | SULFAMETHOXAZOLE | TRIMETHOPRIM |
Therapeutic Class | SULPHONAMIDES |
Indications | Urinary tract infections; typhoid, invasive Salmonellosis; H. influenzae. Infections, exacerbations of chronic bronchitis. |
Caution | Discontinue if skin rash develops. Nausea and vomiting may occur. Sensitivity to sunlight increases while taking this medication. Use a sunscreen when outdoors. C.f. prescribing in renal disease p. More ... |
Dose Range |
Adult: 1-2 tablets every 8-12 hours. Pediatric: 6 weeks - 5 months: ½ teaspoonful every 12 hours. 6 months - 5 years: 1 teaspoonful every 12 hours. 6-12 years: 2 teaspoonsful every 12 hours. Take with a full glass of water and drink several glasses of wat |
Drug Interactions | |
Pregnancy | Co-trimoxazole crosses the placenta and may interfere with folic acid metabolism More ... |
Breast Feeding | Co-trimoxazole is distributed into milk with small risk of kernicterus in jaundi More ... |
Active Ingredient | SULPHASALAZINE |
Therapeutic Class | SULPHONAMIDES |
Indications | Inflammatory bowel disease. |
Caution | Yellow-orange discoloration of skin, urine and other body fluids. Increased sensitivity to sunlight. Do not take if allergic to sulfa-drugs, aspirin or other salicyclates. Take with food to avoid stom More ... |
Dose Range | Adult: 1-2g 4 times daily. Maintenance: 500mg 4 times a day. Pediatric: 2 years and older: 40-60mg/kg daily. Maintenance: 20-30mg/kg daily . |
Drug Interactions | |
Pregnancy |
Theoretical risk of neonatal haemolysis in third trimester; adequate folate supp More ... |
Breast Feeding |
Small amounts in milk (1 report of bloody diarrhoea); theoretical risk of neonat More ... |
Active Ingredient | DOXYCYCLINE |
Therapeutic Class | TETRACYCLINES |
Indications | Exacerbations of chronic bronchitis, brucella, chlamydial infections, my coplasma, acne vulgaris (Low dose), rickettsia. Urinary tract infections (local alternative). |
Caution | Hepatic impairment. Avoid excess exposure to sunlight. C.f. prescribing in liver and renal disease p. 13; 28. |
Dose Range |
200mg on the first day (as a single dose or in divided doses), then 100mg daily. In severe infections the initial dosage is maintained throughout the course of treatment. See BDS supply protocols pg. 3. |
Drug Interactions | |
Pregnancy | Avoid in pregnant women. Administration during the second or third trimester may More ... |
Breast Feeding |
Tetracyclines are excreted in breastmilk and cross the placenta. Consequently th More ... |
Active Ingredient | MINOCYCLINE |
Therapeutic Class | TETRACYCLINES |
Indications | Meningococcal carriers. Active against N. Meningitidis, some Methicillin Resistant Staph & H. Influenzae. Urinary and respiratory tract infections, acne and skin and soft tissue infections. |
Caution | G.I upset, vestibular dysfunction, headache, localized pigmentary disturbances.Not to be used in children under 8 years. C.f. prescribing in liver and renal disease p. 15; 32. |
Dose Range | Adult and Children 12 years and over: 200mg followed by 100mg every 12 hours. Do not exceed 400mg in 24 hours. See BDS supply protocols pg. 3. |
Drug Interactions | |
Pregnancy | Avoid in pregnant women. Administration during the second or third trimester may More ... |
Breast Feeding |
Tetracyclines are excreted in breastmilk and cross the placenta. Consequently th More ... |
Active Ingredient | TETRACYCLINE |
Therapeutic Class | TETRACYCLINES |
Indications | Exacerbations of chronic bronchitis, urninary tract infections, prostatitis, travellers’ diarrhoea, brucella, chlamydia, mycoplasma, rickettsia, acne vulgaris (low dose). Pleural effusions due to mali More ... |
Caution | Drug sensitivity, tooth discoloration, nausea, vomiting, epigastric burning, photosenitivity, vaginal candidiasis, diarrhoea. Renal or hepatic impairment. Not recommended in children under 12 years ol More ... |
Dose Range |
Adult and Children 12 years and over: 250-500mg every 6 hours. See BDS supply protocols pg. 3. |
Drug Interactions | Antacids, milk, oral iron (chelates and reduces absorption) |
Pregnancy | Avoid in pregnant women; effects on skeletal development have been documented in More ... |
Breast Feeding | Should not be given to women who are breast-feeding (although absorption and the More ... |
Active Ingredient | VANCOMYCIN |
Therapeutic Class | GLYCOPEPTIDES |
Indications | Drug of choice for antibiotic - associated pseudomembranous colitis. Anaphylaxis and treatment of endocarditis and other sepsis caused by Gram-positive cocci. Effective in patients with methacillin More ... |
Caution |
Hypotension, flushing, erythema, urticaria, pruritus, nausea, fever, chills. C.f. p rescribing in renal disease p . 38. Administration with other ototoxic or nephrotoxic drugs like aminoglycosides inc More ... |
Dose Range |
Adult: 1g every 12 hours or 500mg every 6 hours. Pediatric: 10- 45mg/kg every 8-12 hours. |
Drug Interactions | |
Pregnancy | Manufacturer advises use only if potential benefit outweighs risk. Plasma-vancom More ... |
Breast Feeding | Present in milk—significant absorption following oral administration unlikely. |
Active Ingredient | CLINDAMYCIN HYDROCHLORIDE |
Therapeutic Class | LINCOMYCINS |
Indications | Staphylococcal bone or joint sepsis, peritonitis (alternative to gentamicin and metronidazole). Effective againstmany anaerobes. Bacteroides fragilis. Gram-positive cocci including penicillin-resis More ... |
Caution | Diarrhoea pseudomembranous colitis. This is the commonest antibiotic causing it (responds to oral metronidazole or vancomycin). Report any excess diarrhoea, do not take anti-diarrhoeal drugs. C.f. pre More ... |
Dose Range | Adult: 150-450mg every 6 hours. Pediatricunder 12 years: 3-6 mg/kg/day every 6 hours. See BDS supply protocols pg. 3. |
Drug Interactions | |
Pregnancy | Not known to be harmful. |
Breast Feeding | Clindamycin has the potential to cause adverse effects on the breastfed infant's More ... |